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Polyacetylenes and Flavonoids Isolated from Flowers of Carthamus tinctorius
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2021-07-12 , DOI: 10.1007/s10600-021-03439-2
Thi Men Ngo 1 , Thi Oanh Vu 1 , Jeong Ah Kim 1 , Thao Quyen Cao 2 , Byung Sun Min 2
Affiliation  

A new acetylene, (8S)-deca-4,6-diyne-1,8-di-O-β-D-glucopyranoside (4), and four known polyacetylenes (1–3 and 5), together with nine known flavonoids (6–14), were isolated from the flowers of Carthamus tinctorius L. The structures of the isolates were elucidated by using spectroscopic analysis, mainly 1D and 2D NMR, HR-MS, and comparison with literature data, as well as enzymatic hydrolysis and Mosher′s esterification methods. All isolated compounds were evaluated for their anti-allergic effects by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T cells. Among them, 6-hydroxykaempferol 3,6-diglucoside (7) inhibited IL-2 production in activated T cells.



中文翻译:

从红花中分离的聚乙炔和黄酮类化合物

一种新的乙炔、(8S)-deca-4,6-diyne-1,8-di-O-β-D-吡喃葡萄糖苷 ( 4 ) 和四种已知的聚乙炔(1-35),以及九种已知的黄酮类化合物( 6-14 ), 从红花的花中分离出来。通过光谱分析, 主要是一维和二维核磁共振, HR-MS, 并与文献数据比较, 以及酶解和酶解, 阐明了分离物的结构。 Mosher 的酯化方法。通过分析 Jurkat T 细胞中白细胞介素 2 (IL-2) 表达的抑制作用来评估所有分离的化合物的抗过敏作用。其中,6-羟基山奈酚 3,6-二葡糖苷 ( 7 ) 抑制活化 T 细胞中 IL-2 的产生。

更新日期:2021-07-12
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