Systematic granulomatosis is a chronic disease that affects the majority of farmed meagre (A. regius). Nutritional imbalances and overcrowding can increase the risk to suffer oxidative stress, and consequently, impact the incidence of granulomatosis. In order to evaluate this, juvenile meagre were fed five isolipidic (16.7%) and isoproteic (49.6%) fish meal and fish oil-based feeds prepared by adding different levels of vitamin C, minerals (Mn, Zn, Se) with constant vitamin E and K (300 and 35 mg/kg respectively): Diet KEC (100 mg/kg C), Diet KEC+Mn/Zn/Se (100 mg/kg C, 40 mg/kg Mn, 200 mg/kg Zn, 1.5 mg/kg Se), Diet KECC (600 mg/kg C), Diet KECCC (1200 mg/kg C), Diet KECCCC (3200 mg/kg C). All diets were tested at 3.20 kg/m³, but diets KECC and KECCCC were also tested at 6.20 kg/m³. Growth performance was only affected by stocking density, being lower at high density. The percentage of fish with granulomas was significantly lower in fish fed with the highest dietary vitamin C contents (KECCC and KECCCC) at low density. TBARS content was correlated with the percentage of granulomas in the liver (R² = 0.9439, y = 0.003x − 0.1242) denoting the involvement of an imbalance oxidative status in the appearance of granulomas. The present results show that high levels of vitamin C (1200–3200 mg/kg C) and low stock density (3.20 kg/m³) favours the growth of juvenile meagre, reducing the lipid peroxidation indicators and decreasing the incidence of granulomas, which confirms that this pathology is mostly triggered by the deficiency of antioxidant nutrients, particularly vitamin C.

中文翻译：

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鱼类放养密度和膳食补充维生素 C 和微量营养素（锰、锌和硒）对幼鱼（Argyrosomus regius）全身性肉芽肿发展的影响

系统性肉芽肿是一种慢性疾病，其影响大多数养殖微薄（的甲。REGIUS）。营养失衡和过度拥挤会增加遭受氧化应激的风险，从而影响肉芽肿的发病率。为了评估这一点，幼鱼被喂食五种异脂 (16.7%) 和异蛋白 (49.6%) 鱼粉和鱼油基饲料，这些饲料是通过添加不同水平的维生素 C、矿物质（锰、锌、硒）和恒定维生素制成的。 E 和 K（分别为 300 和 35 mg/kg）：饮食 KEC（100 mg/kg C），饮食 KEC+Mn/Zn/Se（100 mg/kg C，40 mg/kg Mn，200 mg/kg Zn， 1.5 mg/kg Se)、饮食 KECC (600 mg/kg C)、饮食 KECCC (1200 mg/kg C)、饮食 KECCCC (3200 mg/kg C)。所有日粮均以 3.20 kg/m ³进行测试，但饲料 KECC 和 KECCCC 也在 6.20 kg/m ^{3 下}进行了测试。生长性能仅受放养密度的影响，在高密度下较低。在低密度饲喂最高膳食维生素 C 含量（KECCC 和 KECCCC）的鱼中，肉芽肿鱼的百分比显着降低。TBARS 含量与肝脏中肉芽肿的百分比 ( R ²  = 0.9439, y  = 0.003 x  - 0.1242) 相关，表明不平衡氧化状态参与肉芽肿的出现。目前的结果表明，高水平的维生素 C (1200–3200 mg/kg C) 和低库存密度 (3.20 kg/m ³)有利于幼鱼的生长，降低脂质过氧化指标，降低肉芽肿的发生率，证实这种病理主要是由于缺乏抗氧化营养素，尤其是维生素C。