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Novel composite 3D-printed filament made from fish scale-derived hydroxyapatite, eggshell and polylactic acid via a fused fabrication approach
Additive Manufacturing ( IF 11.0 ) Pub Date : 2021-07-12 , DOI: 10.1016/j.addma.2021.102169
Chin-San Wu, Shan-Shue Wang, Dung-Yi Wu, Wen-Ling Shih

The great green composites, the three-dimensional (3D) printing filaments containing bio-based polyester, natural hydroxyapatite and eggshell composites, were rationally designed and fabricated. We report herein novel bioactive 3D-printing filaments prepared from fish scale-derived hydroxyapatite (FHAp), polylactic acid (PLA) and a natural antibacterial agent from eggshell (EGS). The preparation of FHAp and EGS from Asian sea bass (Lates calcarifer) scales and chicken EGS, respectively, are also described. The structural, mechanical and thermal properties of the resulting composites were evaluated together with the water contact angle, free-radical scavenging ability and antibacterial effects. Polylactic acid typically exhibits poor free-radical scavenging ability and no antibacterial effect. Incorporating FHAp and EGS as fillers in the processed filament significantly enhanced the functional performance of the PLA composite. The addition of FHAp enhanced cell attachment and proliferation, suggesting osteointegration potential. The addition of EGS containing CaO component provided the antibacterial properties. PLA/EFHAp composites were porous and displayed excellent tensile strength, proliferation of mouse embryonic fibroblasts in vitro, antioxidant properties, water resistance and antibacterial properties. In addition, the developed PLA/FHAp and EFHAp filaments are amenable to large-scale production and implementation in a variety of in vivo implants of bone or other biomedical appliances.



中文翻译:

通过融合制造方法由鱼鳞衍生的羟基磷灰石、蛋壳和聚乳酸制成的新型复合 3D 打印长丝

伟大的绿色复合材料,包含生物基聚酯、天然羟基磷灰石和蛋壳复合材料的三维(3D)打印长丝,经过合理设计和制造。我们在此报告了由鱼鳞衍生的羟基磷灰石 (FHAp)、聚乳酸 (PLA) 和来自蛋壳的天然抗菌剂 (EGS) 制备的新型生物活性 3D 打印长丝。亚洲鲈鱼(Lates calcarifer) FHAp和EGS的制备) 鳞片和鸡 EGS 也分别进行了描述。对所得复合材料的结构、机械和热性能以及水接触角、自由基清除能力和抗菌作用进行了评估。聚乳酸通常表现出较差的自由基清除能力且无抗菌作用。在加工的长丝中加入 FHAp 和 EGS 作为填料显着提高了 PLA 复合材料的功能性能。FHAp 的添加增强了细胞附着和增殖,表明骨整合潜力。添加含有 CaO 组分的 EGS 提供了抗菌性能。PLA/EFHAp 复合材料是多孔的,显示出优异的拉伸强度、体外小鼠胚胎成纤维细胞的增殖、抗氧化性能、防水和抗菌性能。此外,开发的 PLA/FHAp 和 EFHAp 细丝适合大规模生产并应用于各种骨或其他生物医学器械的体内植入物。

更新日期:2021-07-15
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