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Brain-Derived Neurotrophic Factor Gene Polymorphism Predicts Response to Continuous Theta Burst Stimulation in Chronic Stroke Patients
Neuromodulation: Technology at the Neural Interface ( IF 2.8 ) Pub Date : 2021-07-12 , DOI: 10.1111/ner.13495
Shreya Parchure 1 , Denise Y Harvey 1 , Priyanka P Shah-Basak 2 , Laura DeLoretta 1 , Rachel Wurzman 1 , Daniela Sacchetti 1 , Olufunsho Faseyitan 1 , Falk W Lohoff 3 , Roy H Hamilton 1
Affiliation  

The efficacy of repetitive transcranial magnetic stimulation (rTMS) in clinically relevant neuroplasticity research depends on the degree to which stimulation induces robust, reliable effects. The high degree of interindividual and intraindividual variability observed in response to rTMS protocols, such as continuous theta burst stimulation (cTBS), therefore represents an obstacle to its utilization as treatment for neurological disorders. Brain-derived neurotrophic factor (BDNF) is a protein involved in human synaptic and neural plasticity, and a common polymorphism in the BDNF gene (Val66Met) may influence the capacity for neuroplastic changes that underlie the effects of cTBS and other rTMS protocols. While evidence from healthy individuals suggests that Val66Met polymorphism carriers may show diminished or facilitative effects of rTMS compared to their homozygous Val66Val counterparts, this has yet to be demonstrated in the patient populations where neuromodulatory therapies are most relevant.

中文翻译:

脑源性神经营养因子基因多态性预测慢性中风患者对持续 Theta 爆发刺激的反应

重复经颅磁刺激 (rTMS) 在临床相关神经可塑性研究中的功效取决于刺激产生稳健、可靠效果的程度。因此,在对 rTMS 方案(例如连续 theta 爆发刺激 (cTBS))的反应中观察到的高度个体间和个体内变异性,对其用作神经系统疾病的治疗构成了障碍。脑源性神经营养因子 (BDNF) 是一种参与人类突触和神经可塑性的蛋白质,BDNF 基因 (Val66Met) 中常见的多态性可能会影响神经可塑性变化的能力,而神经可塑性变化是 cTBS 和其他 rTMS 方案影响的基础。虽然来自健康个体的证据表明,与纯合 Val66Val 对应物相比,Val66Met 多态性携带者可能表现出 rTMS 的减弱或促进作用,但这一点尚未在神经调节治疗最相关的患者群体中得到证实。
更新日期:2021-07-12
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