The detection of a peripheral immune cell signature that specifically reflects autoimmunity in type 1 diabetes would enable the prediction and staging of disease on an individual basis. However, defining such a signature is technically challenging. Reliable interpretation of immune cell-related biomarkers depends on their inherent variability and, to understand this variability, longitudinal analyses are required.

中文翻译：

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外周自身反应性 CD8 T 细胞频率变化太大，无法作为人类 1 型糖尿病疾病进展的可靠预测因子

检测特异性反映 1 型糖尿病自身免疫性的外周免疫细胞特征将能够在个体基础上预测和分期疾病。然而，定义这样的签名在技术上具有挑战性。对免疫细胞相关生物标志物的可靠解释取决于其固有的可变性，为了理解这种可变性，需要进行纵向分析。