Inherently safer design is the most proactive approach to manage risk, as referred by scientists and experts. Researchers have adopted various methods in evaluating inherent safety indices like parameter-based indexing, risk-based indexing, consequence-based indexing, etc. However, the existing approaches have their limitations. The present paper focuses on establishing an inherent system safety index (ISSI) to evaluate inherently safer design during the concept development stage. The analysis starts by identifying a non-harmful system's inherent safety characteristics and related parameters. Four subindexes, determined from the non-harmful system's characteristics, are established using their relevant parameters. The safety of the chemical process system, the health of workers, and the environment's safety can be assured by selecting relevant parameters. Parameters are scored based on their deviation from the non-harmful condition. The sum of the deviations of the parameters gives the value of the inherent safety index. The case study looks at various routes of Methyl Methacrylate (MMA). According to the present case study, MMA production followed by Tertiary butyl alcohol is the safest route given health, safety, and environmental perspective. This approach helps overcome the limitation of parameter-based indexing, which arises from selecting predefined fixed parameters that become invalid in case of system variation or significant modification of the system. Besides, it considers the complexity and vulnerability that arises from the interaction of various factors|, which increase predetermined risk calculated at the design stage when the system is in operation. The subindices can be used individually if a focus is needed in a definite section of a system with a particular application or a smaller portion. This method is helpful for the industry in designing a safer plant considering the health, safety, and environmental perspective at the concept development stage.

正如科学家和专家所说，本质上更安全的设计是管理风险的最积极主动的方法。研究人员采用了基于参数的索引、基于风险的索引、基于结果的索引等各种方法来评估固有安全指标，但是现有的方法有其局限性。本论文的重点是建立固有系统安全指数 (ISSI)，以在概念开发阶段评估固有安全设计。分析首先确定无害系统的固有安全特性和相关参数。根据无害系统的特性确定的四个子指标使用它们的相关参数建立。化学工艺系统的安全、工人的健康和环境' 可以通过选择相关参数来保证安全性。参数根据它们与无害条件的偏差进行评分。参数偏差的总和给出了固有安全指数的值。该案例研究着眼于甲基丙烯酸甲酯 (MMA) 的各种途径。根据目前的案例研究，考虑到健康、安全和环境的观点，MMA 生产，然后是叔丁醇是最安全的路线。这种方法有助于克服基于参数的索引的限制，这是由于选择了预定义的固定参数，这些参数在系统变化或系统重大修改的情况下变得无效。此外，它考虑了各种因素相互作用产生的复杂性和脆弱性|，这增加了在系统运行时在设计阶段计算的预定风险。如果需要重点关注，可以单独使用子索引具有特定应用或较小部分的系统的确定部分。这种方法有助于行业在概念开发阶段从健康、安全和环境角度设计更安全的工厂。