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Body mass index and height in young adult men in relation to subsequent risk of mood disorder
European Journal of Epidemiology ( IF 13.6 ) Pub Date : 2021-07-10 , DOI: 10.1007/s10654-021-00783-z
Gunhild Tidemann Okholm 1, 2 , Terese Sara Høj Jørgensen 2 , Maarten Pieter Rozing 3, 4 , Marie Kim Wium-Andersen 2 , Ida Kim Wium-Andersen 2, 3 , Martin Balslev Jørgensen 3 , Thorkild I A Sørensen 5, 6 , Merete Osler 2, 5
Affiliation  

Adolescence represents an important period in brain and mental development, which raises the question of whether measures of body size at entry into adult life influence the risk of developing mood disorders. We examined the association of BMI and height in a cohort of young men with risk of mood disorders throughout life. The study included 630,807 Danish men born 1939–1959 and 1983–1997 with measures of height and weight at conscription board examinations. Psychiatrist’s diagnosis of mood disorders was obtained from national patient registries from 1969 to 2016. The associations of BMI and height with mood disorders were estimated by Cox proportional hazard regression analyses adjusting for education, cognitive ability, migration status drug and alcohol misuse. During a mean follow-up of 26.3 years, 2,608 (0.6%) and 19,690 (3.1%) men were diagnosed with bipolar disorder and depression, respectively. We found an inverse linear association of BMI with risk of bipolar disorder, whereas the association of BMI with depression was curve-linear with a decline in risk until BMI around 25 kg/m2, and an almost constant risk across the BMI range above 25 kg/m2. Height was not associated with bipolar disorder or depression. Comparison of brothers, assumed to share family factors of possible influence on the risk of mood disorders, showed similar results although with wider confidence intervals. BMI in the lower range at men’s entry into adulthood is inversely associated with risk of bipolar disorder and depression throughout adult life, whereas height is not related.



中文翻译:

年轻成年男性的体重指数和身高与随后的情绪障碍风险的关系

青春期是大脑和智力发育的重要时期,这就提出了一个问题,即进入成年期时的体型测量是否会影响发生情绪障碍的风险。我们研究了一组终生有情绪障碍风险的年轻男性的 BMI 与身高之间的关联。该研究包括 630,807 名出生于 1939-1959 年和 1983-1997 年的丹麦男性,他们在征兵委员会考试中测量了身高和体重。精神科医生对情绪障碍的诊断是从 1969 年至 2016 年的全国患者登记处获得的。 BMI 和身高与情绪障碍的关联是通过 Cox 比例风险回归分析估计的,并调整了教育、认知能力、移民状态、药物和酒精滥用。在平均 26.3 年的随访期间,2,608 (0.6%) 和 19,690 (3. 1%) 男性分别被诊断出患有躁郁症和抑郁症。我们发现 BMI 与双相情感障碍风险呈负线性关联,而 BMI 与抑郁症的关联呈曲线线性关系,风险下降直至 BMI 约为 25 kg/m2,并且在 25 kg/m 2以上的 BMI 范围内几乎恒定的风险。身高与双相情感障碍或抑郁症无关。兄弟的比较,假定共享可能影响情绪障碍风险的家庭因素,显示了相似的结果,尽管置信区间更宽。男性进入成年期时处于较低范围的 BMI 与成年后双相情感障碍和抑郁症的风险呈负相关,而身高则没有相关性。

更新日期:2021-07-12
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