Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. Recent high-resolution transcriptional and histological analyses have enriched our knowledge of LN FRC genetic and spatial heterogeneities. Here, we summarize updated anatomic, phenotypic, and functional identities of FRC subsets, delve into topological and transcriptional remodeling of FRCs in inflammation, and illustrate the crosstalk between FRCs and immune cells. Discussing FRC functions in immunity and tolerance, we highlight state-of-the-art FRC-based therapeutic approaches for maintaining physiological homeostasis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-related diseases.

引发免疫反应的淋巴结 (LN) 由成纤维细胞网状细胞 (FRC) 组织成独特的隔室。FRC 通过支持 LN 架构、招募免疫细胞、协调免疫细胞串扰和呈递抗原来印记免疫反应。最近的高分辨率转录和组织学分析丰富了我们对 LN FRC 遗传和空间异质性的了解。在这里，我们总结了 FRC 亚群的最新解剖、表型和功能特性，深入研究了炎症中 FRC 的拓扑和转录重塑，并说明了 FRC 和免疫细胞之间的串扰。讨论 FRC 在免疫和耐受中的功能，我们强调了基于 FRC 的最先进的治疗方法，用于维持生理稳态，引导保护性免疫，