Abstract

Autoimmune disease (AID) is a condition in which the immune system breaks down and starts to attack the body. Some common AIDs include systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus and so forth. The changes in T-cell receptor (TCR) repertoire have been found in several autoimmune diseases, and may be responsible for the breakdown of peripheral immune tolerance. In this review, we discussed the processes of TCR revision in peripheral immune environment, the changes in TCR repertoire that occurred in various AIDs, and the specifically expanded T cell clones. We hope our discussion can provide insights for the future studies, helping with the discovery of disease biomarkers and expanding the strategies of immune-targeted therapy.

• Highlights

• Restricted TCR repertoire and biased TCR-usage are found in a variety of AIDs.

• TCR repertoire shows tissue specificity in a variety of AID diseases.

• The relationship between TCR repertoire diversity and disease activity is still controversial in AIDs.

• Dominant TCR clonotypes may help to discover new disease biomarkers and expand the strategies of immune-targeted therapy.

摘要

自身免疫性疾病 (AID) 是一种免疫系统崩溃并开始攻击身体的疾病。一些常见的艾滋病包括系统性红斑狼疮、类风湿性关节炎、1 型糖尿病等。在几种自身免疫性疾病中发现了 T 细胞受体 (TCR) 库的变化，并且可能是外周免疫耐受性崩溃的原因。在这篇综述中，我们讨论了外周免疫环境中 TCR 修正的过程、在各种 AIDs 中发生的 TCR 库的变化，以及特异性扩增的 T 细胞克隆。我们希望我们的讨论可以为未来的研究提供见解，帮助发现疾病生物标志物并扩展免疫靶向治疗的策略。

• 强调

• 在各种 AID 中发现了受限的 TCR 库和有偏见的 TCR 使用。

• TCR 库在多种 AID 疾病中显示出组织特异性。

• TCR 库多样性与疾病活动之间的关系在艾滋病中仍然存在争议。

• 显性 TCR 克隆型可能有助于发现新的疾病生物标志物并扩展免疫靶向治疗的策略。