Importance ASD diagnosis remains behavior-based and the median age of the first diagnosis remains unchanged at ∼52 months, which is nearly 5 years after its first trimester origin. Long delays between ASD’s prenatal onset and eventual diagnosis likely is a missed opportunity. However, accurate and clinically-translatable early-age diagnostic methods do not exist due to ASD genetic and clinical heterogeneity. There is a need for early-age diagnostic biomarkers of ASD that is robust against its heterogeneity.

中文翻译：

---

用于 1 至 4 岁 ASD 分子诊断的高精度集成分类器

重要性ASD 诊断仍然基于行为，首次诊断的中位年龄保持不变，约为 52 个月，距其最初三个月起源近 5 年。ASD 的产前发病和最终诊断之间的长期延迟可能是一个错失的机会。然而，由于 ASD 遗传和临床异质性，不存在准确且可临床转化的早期诊断方法。需要 ASD 的早期诊断生物标志物，以对抗其异质性。