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Vitamin D as a Potential Preventive Agent For Young Women's Breast Cancer
Cancer Prevention Research ( IF 3.3 ) Pub Date : 2021-09-01 , DOI: 10.1158/1940-6207.capr-21-0114
Sarah M Bernhardt 1, 2 , Virginia F Borges 3, 4 , Pepper Schedin 1, 2, 4
Affiliation  

Clinical studies backed by research in animal models suggest that vitamin D may protect against the development of breast cancer, implicating vitamin D as a promising candidate for breast cancer prevention. However, despite clear preclinical evidence showing protective roles for vitamin D, broadly targeted clinical trials of vitamin D supplementation have yielded conflicting findings, highlighting the complexity of translating preclinical data to efficacy in humans. While vitamin D supplementation targeted to high-risk populations is a strategy anticipated to increase prevention efficacy, a complimentary approach is to target transient, developmental windows of elevated breast cancer risk. Postpartum mammary gland involution represents a developmental window of increased breast cancer promotion that may be poised for vitamin D supplementation. Targeting the window of involution with short-term vitamin D intervention may offer a simple, cost-effective approach for the prevention of breast cancers that develop postpartum. In this review, we highlight epidemiologic and preclinical studies linking vitamin D deficiency with breast cancer development. We discuss the underlying mechanisms through which vitamin D deficiency contributes to cancer development, with an emphasis on the anti-inflammatory activity of vitamin D. We also discuss current evidence for vitamin D as an immunotherapeutic agent and the potential for vitamin D as a preventative strategy for young woman's breast cancer.

中文翻译:

维生素 D 作为年轻女性乳腺癌的潜在预防剂

动物模型研究支持的临床研究表明,维生素 D 可以预防乳腺癌的发展,这表明维生素 D 是预防乳腺癌的有希望的候选者。然而,尽管有明确的临床前证据显示维生素 D 具有保护作用,但针对维生素 D 补充剂的广泛靶向临床试验产生了相互矛盾的结果,突出了将临床前数据转化为人类疗效的复杂性。虽然针对高危人群的维生素 D 补充剂是一种有望提高预防效果的策略,但一种补充方法是针对乳腺癌风险升高的短暂、发育窗口。产后乳腺退化代表了增加乳腺癌促进的发展窗口,可能需要补充维生素 D。通过短期维生素 D 干预针对复旧窗口可能为预防产后发生的乳腺癌提供一种简单、经济有效的方法。在这篇综述中,我们重点介绍了将维生素 D 缺乏与乳腺癌发展联系起来的流行病学和临床前研究。我们讨论了维生素 D 缺乏导致癌症发展的潜在机制,重点是维生素 D 的抗炎活性。我们还讨论了维生素 D 作为免疫治疗剂的当前证据以及维生素 D 作为预防策略的潜力对于年轻女性的乳腺癌。我们强调将维生素 D 缺乏与乳腺癌发展联系起来的流行病学和临床前研究。我们讨论了维生素 D 缺乏导致癌症发展的潜在机制,重点是维生素 D 的抗炎活性。我们还讨论了维生素 D 作为免疫治疗剂的当前证据以及维生素 D 作为预防策略的潜力对于年轻女性的乳腺癌。我们强调将维生素 D 缺乏与乳腺癌发展联系起来的流行病学和临床前研究。我们讨论了维生素 D 缺乏导致癌症发展的潜在机制,重点是维生素 D 的抗炎活性。我们还讨论了维生素 D 作为免疫治疗剂的当前证据以及维生素 D 作为预防策略的潜力对于年轻女性的乳腺癌。
更新日期:2021-09-01
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