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Effect of induced acute metabolic alkalosis on the V̇E/V̇CO2 response to exercise in healthy adults
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-07-10 , DOI: 10.1016/j.resp.2021.103740
Joshua Broadman 1 , Dennis Jensen 2
Affiliation  

We tested the hypothesis that increasing the respiratory control systems’ arterial PCO2 equilibrium point via induced acute metabolic alkalosis by ingestion of sodium bicarbonate (NaHCO3, 0.3 g/kg) would decrease the ventilatory equivalent for CO2 (V̇E/V̇CO2) at its lowest point (“nadir”) during constant-load cycle exercise testing performed at 80 % of peak power output in 18 healthy young adults. Compared to the sodium chloride (4 g) control condition, ingestion of NaHCO3: increased arterialized venous pH, HCO3- and PCO2 at rest by 0.05 ± 0.01 units (mean ± SE), 6.4 ± 0.4 mEq/L and 4.3 ± 0.7 mmHg, respectively (all p < 0.0001); and decreased the V̇E/V̇CO2 nadir during exercise by 9.4 % (p < 0.0001) secondary to a 4.7 ± 1.8 L/min decrease in V̇E (p = 0.019). In conclusion, induced acute metabolic alkalosis by ingestion of NaHCO3 decreased the V̇E/V̇CO2 response to strenuous exercise in healthy adults.



中文翻译:

诱发急性代谢性碱中毒对健康成人运动后 V̇E/V̇CO2 反应的影响

我们检验了以下假设:通过摄入碳酸氢钠(NaHCO 3 ,0.3 g/kg)诱导的急性代谢性碱中毒增加呼吸控制系统的动脉 PCO 2平衡降低CO 2的换气当量(V̇ E /V̇CO 2)在 18 名健康年轻人中以峰值功率输出的 80% 进行的恒定负载循环运动测试期间的最低点(“最低点”)。与氯化钠 (4 g) 对照条件相比,摄入 NaHCO 3:增加动脉化静脉 pH、HCO 3 - 和 PCO 2静息时分别为 0.05 ± 0.01 个单位(平均值 ± SE)、6.4 ± 0.4 mEq/L 和 4.3 ± 0.7 mmHg(所有 p < 0.0001);并将运动期间的 V̇ E /V̇CO 2最低点降低 9.4 % (p < 0.0001),继而 V̇ E降低 4.7 ± 1.8 L/min (p = 0.019)。总之,摄入 NaHCO 3诱发的急性代谢性碱中毒降低了健康成人对剧烈运动的 V̇ E /V̇CO 2反应。

更新日期:2021-07-24
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