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SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up
Journal of Perinatal Medicine ( IF 2.4 ) Pub Date : 2021-07-01 , DOI: 10.1515/jpm-2021-0166
Katharina Rathberger 1 , Sebastian Häusler 1, 2 , Sven Wellmann 3 , Marco Weigl 1 , Florian Langhammer 3 , Maria Victoria Bazzano 4 , Andreas Ambrosch 5 , Sara Fill Malfertheiner 1, 6
Affiliation  

Objectives In the current Severe Acute Respiratory Distress Coronavirus 2 (SARS-CoV-2) pandemic there is still great uncertainty about the effects of an infection in pregnancy especially regarding a possible fetal transmission of antibodies to SARS-CoV-2 and the longevity of this immunity. Methods Sixteen women who were infected with SARS-CoV-2 during pregnancy and their offspring were included. The antibody response to SARS-CoV-2 was measured in mother and umbilical cord blood peripartum and in a follow-up examination 6–11 weeks after birth. Medical history, symptoms regarding SARS-CoV-2, obstetric and neonatal information were queried following recommendations by the WHO. Results A total of 73% of the women and one third of the infants developed antibodies to SARS-CoV-2 spike (S) protein receptor binding domain (RBD), with a long interval between infection and birth proving favorable for a transplacentar transfer of antibodies to the neonates. All infants showed declining or vanishing antibody-titers in the follow-up examination, while the titers of their mothers were stable or even increased. Conclusions Our results demonstrate that transplacental transfer of SARS-CoV-2-specific antibodies is possible, but also indicate that the immunity that may be gained as a result might decrease in newborns postpartum. This provides important evidence that could be useful for further studies covering vaccination during pregnancy.

中文翻译:

妊娠期 SARS-CoV-2 和可能的免疫转移:围产期母婴抗体水平评估和纵向随访

目标 在当前严重急性呼吸窘迫冠状病毒 2 (SARS-CoV-2) 大流行中,妊娠期感染的影响仍然存在很大的不确定性,特别是关于 SARS-CoV-2 抗体可能在胎儿中传播以及这种情况的寿命免疫。方法 16 名怀孕期间感染 SARS-CoV-2 的妇女及其后代被纳入研究。在母亲和围产期脐带血中以及在出生后 6-11 周的随访中测量了对 SARS-CoV-2 的抗体反应。根据世界卫生组织的建议,询问了病史、SARS-CoV-2 症状、产科和新生儿信息。结果 共有 73% 的妇女和三分之一的婴儿产生了针对 SARS-CoV-2 刺突 (S) 蛋白受体结合域 (RBD) 的抗体,感染和出生之间的长时间间隔证明有利于抗体经胎盘转移给新生儿。所有婴儿在随访检查中均显示抗体滴度下降或消失,而其母亲的滴度稳定甚至增加。结论 我们的结果表明 SARS-CoV-2 特异性抗体的经胎盘转移是可能的,但也表明由此产生的免疫力可能会在新生儿产后降低。这提供了重要的证据,可用于进一步研究涵盖怀孕期间的疫苗接种。而他们母亲的滴度稳定甚至增加。结论 我们的结果表明 SARS-CoV-2 特异性抗体的经胎盘转移是可能的,但也表明由此产生的免疫力可能会在新生儿产后降低。这提供了重要的证据,可用于进一步研究涵盖怀孕期间的疫苗接种。而他们母亲的滴度稳定甚至增加。结论 我们的结果表明 SARS-CoV-2 特异性抗体的经胎盘转移是可能的,但也表明由此产生的免疫力可能会在新生儿产后降低。这提供了重要的证据,可用于进一步研究涵盖怀孕期间的疫苗接种。
更新日期:2021-07-12
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