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Lipid Nutrition in Asthma
Cell Biochemistry and Biophysics ( IF 2.6 ) Pub Date : 2021-07-09 , DOI: 10.1007/s12013-021-01020-w
Patrick J Oliver 1, 2 , Sukruthi Arutla 1, 2 , Anita Yenigalla 1, 2 , Thomas J Hund 2 , Narasimham L Parinandi 1, 2
Affiliation  

Asthma is a heterogeneous pulmonary disease that has constantly increased in prevalence over the past several decades. Primary symptoms include airway constriction, airway hyperresponsiveness, and airway remodeling with additional symptoms such as shortness of breath, wheezing, and difficulty breathing. Allergic asthma involves chronic inflammation of the lungs, and the rise in its yearly diagnosis is potentially associated with the increased global consumption of foods similar to the western diet. Thus, there is growing interest into the link between diet and asthma symptoms, with mounting evidence for an important modulatory role for dietary lipids. Lipids can act as biological mediators in both a proinflammatory and proresolution capacity. Fatty acids play key roles in signaling and in the production of mediators in the allergic and inflammatory pathways. The western diet leads to a disproportionate ω-6:ω-3 ratio, with drastically increased ω-6 levels. To counteract this, consumption of fish and fish oil and the use of dietary oils with anti-inflammatory properties such as olive and sesame oil can increase ω-3 and decrease ω-6 levels. Increasing vitamin intake, lowering LDL cholesterol levels, and limiting consumption of oxidized lipids can help reduce the risk of asthma and the exacerbation of asthmatic symptoms. These dietary changes can be achieved by increasing intake of fruits, vegetables, nuts, oily fish, seeds, animal-related foods (eggs, liver), cheeses, grains, oats, and seeds, and decreasing consumption of fried foods (especially fried in reused oils), fast foods, and heavily processed foods.



中文翻译:

哮喘的脂质营养

哮喘是一种异质性肺部疾病,在过去几十年中患病率不断增加。主要症状包括气道收缩、气道高反应性和气道重塑以及其他症状,如呼吸短促、喘息和呼吸困难。过敏性哮喘涉及肺部的慢性炎症,其年度诊断的增加可能与全球类似西方饮食的食物消费增加有关。因此,人们对饮食和哮喘症状之间的联系越来越感兴趣,越来越多的证据表明饮食脂质具有重要的调节作用。脂质可以作为促炎和促消退能力的生物介质。脂肪酸在过敏和炎症途径中的信号传导和介质产生中起关键作用。西方饮食导致 ω-6:ω-3 比例不成比例,ω-6 水平急剧增加。为了抵消这种情况,食用鱼和鱼油以及使用具有抗炎特性的膳食油(如橄榄油和芝麻油)可以增加 ω-3 并降低 ω-6 水平。增加维生素摄入量、降低 LDL 胆固醇水平和限制氧化脂质的消耗有助于降低哮喘风险和哮喘症状恶化。这些饮食改变可以通过增加水果、蔬菜、坚果、油性鱼、种子、动物相关食物(鸡蛋、肝脏)、奶酪、谷物、燕麦和种子的摄入量以及减少油炸食品(尤其是油炸食品)的摄入来实现。重复使用的油),快餐,

更新日期:2021-07-12
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