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Internet-delivered cognitive-behaviour therapy (ICBT) for obsessive-compulsive disorder when delivered as routine clinical care: A phase IV clinical trial
Journal of Anxiety Disorders ( IF 10.3 ) Pub Date : 2021-07-09 , DOI: 10.1016/j.janxdis.2021.102444
Bethany M Wootton 1 , Eyal Karin 2 , Blake F Dear 2 , Lauren Staples 3 , Olav Nielssen 3 , Rony Kayrouz 3 , Nickolai Titov 2
Affiliation  

Cognitive-behaviour therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD), but many patients experience difficulty accessing this treatment. Internet-delivered CBT (ICBT) enhances access to CBT for individuals with OCD and has been shown to be efficacious in Phase I, II, and III clinical trials. However, there are fewer studies investigating ICBT for OCD in Phase IV clinical trials, which demonstrate the effectiveness of the intervention when provided as part of routine care. The aim of the present study was to report on the effectiveness of ICBT for OCD, using data from Australia’s MindSpot Clinic, a federally funded treatment service that provides free ICBT to Australian adults with anxiety, depression, and pain conditions. A total of 225 MindSpot users (68 % female; Mage = 34.82; SD = 11.02) were included in the study. Within-group effect sizes at post-treatment on the Yale-Brown Obsessive-Compulsive Scale, indicated medium effect sizes (g = 0.6; 95 % CI: 0.5−0.7), increasing to large effects at three-month follow up (g = 0.9; 95 % CI: 0.8–1.0). Effects on secondary outcome measures including measures of depression, generalized anxiety, and psychological distress ranged from (g = 0.5–0.6) at post-treatment and (g = 0.5–0.7) at three-month follow up. Results from benchmarking analyses indicated that the results from routine care were significantly smaller than those found in a recent clinical trial using the same treatment protocol. The results indicate that ICBT delivered in real world settings is associated with meaningful improvements in OCD symptoms, however future research may wish to examine which patients respond best to this treatment approach and how to enhance outcomes.



中文翻译:

作为常规临床护理提供的针对强迫症的互联网提供的认知行为疗法 (ICBT):一项 IV 期临床试验

认知行为疗法 (CBT) 是一种治疗强迫症 (OCD) 的有效方法,但许多患者在接受这种治疗时遇到困难。互联网交付的 CBT (ICBT) 增强了强迫症患者获得 CBT 的机会,并且在 I、II 和 III 期临床试验中已被证明是有效的。然而,在 IV 期临床试验中研究 ICBT 治疗强迫症的研究较少,这些研究证明了干预作为常规护理的一部分提供时的有效性。本研究的目的是使用澳大利亚 MindSpot Clinic 的数据报告 ICBT 对 OCD 的有效性,MindSpot Clinic 是一项联邦资助的治疗服务,为患有焦虑、抑郁和疼痛的澳大利亚成年人提供免费 ICBT。共有 225 MindSpot 用户(68% 女性;M年龄 = 34.82;SD = 11.02) 被纳入研究。Yale-Brown 强迫症量表治疗后的组内效应量表明中等效应量 ( g = 0.6;95 % CI: 0.5-0.7),在三个月随访时增加到大效应 ( g = 0.9;95% CI:0.8–1.0)。对次要结果测量的影响包括抑郁、广泛性焦虑和心理困扰的测量,治疗后范围为 ( g = 0.5–0.6) 和 ( g= 0.5–0.7) 在三个月的随访中。基准分析的结果表明,常规护理的结果明显小于最近使用相同治疗方案进行的临床试验中发现的结果。结果表明,在现实世界环境中提供的 ICBT 与 OCD 症状的显着改善相关,但是未来的研究可能希望检查哪些患者对这种治疗方法反应最好,以及如何提高结果。

更新日期:2021-07-15
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