Castleman disease (CD) is a rare chronic lymphoproliferative disease with unknown etiology and pathogenesis disease. When the lesion is located in the mediastinum, the diagnosis of CD is easy. However, if the lesion presents as a perigastric mass mimicking other subserosal gastric mesenchymal tumors, the diagnosis can be challenging. As few sonographic manifestations of hyaline-vascular variant CD, especially contrast-enhanced ultrasound (CEUS) imaging, as well as computed tomography (CT) and histopathological imaging, have been reported in literature, this case may provide a vivid example of a comprehensive CEUS and CT usage in the diagnosis and surgery with regard to CD. This report presents a case of a 50-year-old female diagnosed with hyaline-vascular variant CD in a random physical examination, the ultrasound examination first revealed a 24.3 mm × 15.4 mm hypoechogenic lesion abutting the stomach, esophagus, and liver, which was under the suspicion of gastrointestinal stromal tumor. Following a series of medical examinations, including CEUS, CT, postoperative histopathological examination, and immunohistochemical analysis, the patient was diagnosed with hyaline-vascular variant unicentric CD. After the mass was completely excised through laparoscopic surgery, the woman recovered very well without recurrence during a follow-up period of 15 months. Thus, mastering ultrasound and CT-imaging characteristics of CD and applying ultrasound and CT examination together would do help to preoperative diagnosis.
Case Rep Gastroenterol 2020;15:632–638

中文翻译：

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胃周围透明血管变异型卡斯尔曼病

Castleman病（CD）是一种罕见的慢性淋巴组织增生性疾病，病因和发病机制不明。当病变位于纵隔时，CD的诊断很容易。然而，如果病变表现为类似其他浆膜下胃间叶质肿瘤的胃周肿块，则诊断可能具有挑战性。由于透明血管变异型 CD 的超声表现，尤其是对比增强超声 (CEUS) 成像，以及计算机断层扫描 (CT) 和组织病理学成像，在文献中鲜有报道，因此该病例可能是全面 CEUS 的生动例子和 CT 在 CD 诊断和手术中的应用。本报告介绍了一例在随机体检中被诊断为透明血管变异型 CD 的 50 岁女性病例，超声检查首先显示为 24。胃、食管、肝脏3mm×15.4mm低回声病灶，怀疑胃肠道间质瘤。经CEUS、CT、术后组织病理学检查、免疫组化分析等一系列医学检查，患者被诊断为透明血管变异型单中心CD。经腹腔镜手术完全切除肿块后，该妇女恢复良好，随访15个月未复发。因此，掌握CD的超声和CT影像特点，结合超声和CT检查有助于术前诊断。包括CEUS、CT、术后组织病理学检查和免疫组化分析，患者被诊断为透明血管变异型单中心CD。经腹腔镜手术完全切除肿块后，该妇女恢复良好，随访15个月未复发。因此，掌握CD的超声和CT影像特点，结合超声和CT检查有助于术前诊断。包括CEUS、CT、术后组织病理学检查和免疫组化分析，患者被诊断为透明血管变异型单中心CD。经腹腔镜手术完全切除肿块后，该妇女恢复良好，随访15个月未复发。因此，掌握CD的超声和CT影像特点，结合超声和CT检查有助于术前诊断。
Case Rep Gastroenterol 2020；15:632–638