Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder,Journal of Child Psychology and Psychiatry

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Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder
Journal of Child Psychology and Psychiatry ( IF 7.6 ) Pub Date : 2021-07-07 , DOI: 10.1111/jcpp.13479
Hugo Peyre _{1,

2,

3,

4} , Tabea Schoeler ₁ , Chaoyu Liu ₁ , Camille Michèle Williams ₂ , Nicolas Hoertel _{5,

6} , Alexandra Havdahl _{7,

8,

9} , Jean-Baptiste Pingault _{1,

10}

Affiliation

Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Laboratoire de Sciences Cognitives et Psycholinguistique (ENS, EHESS, CNRS), Ecole Normale Supérieure, PSL University, Paris, France.
Neurodiderot, INSERM UMR 1141, Paris Diderot University, Paris, France.
Department of Child and Adolescent Psychiatry, Robert Debré Hospital, APHP, Paris, France.
INSERM UMR 894, Psychiatry and Neurosciences Center, Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France.
Department of Psychiatry, Corentin Celton Hospital, APHP, Issy-les-Moulineaux, Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France.
Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two highly heritable neurodevelopmental disorders. Several lines of evidence point towards the presence of shared genetic factors underlying ASD and ADHD. We conducted genomic analyses of common risk variants (i.e. single nucleotide polymorphisms, SNPs) shared by ASD and ADHD, and those specific to each disorder.

中文翻译：

结合多变量基因组方法来阐明自闭症谱系障碍和注意力缺陷多动障碍之间的共病

注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）是两种高度遗传的神经发育障碍。有几条证据表明存在 ASD 和 ADHD 的共同遗传因素。我们对 ASD 和 ADHD 共有的常见风险变异（即单核苷酸多态性，SNP）以及每种疾病特有的风险变异进行了基因组分析。

更新日期：2021-07-07

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