The growth of pathogenic bacteria seriously threatens human health. Effective inhibition of pathogenic bacteria in the human body and the surrounding environment is of great urgency. In this work, we propose a strategy in preparing bacteriophage-like gold nanoparticles (B-AuNPs) for antibacterial applications. B-AuNPs were prepared by multiple in-situ reducing reactions on the surface of AuNPs. It was shown that the secondary-reduced AuNPs (B₁-AuNPs) have a bacteriophage shaped morphology. Under near infrared laser, B₁-AuNPs could almost completely inhibit bacterial growth at low concentrations within 5 min, due to the combined effects of increased temperature and reactive oxygen species (ROS). Moreover, B-AuNPs can be easily separated from the dead bacteria and the recycled B-AuNPs remain the high antibacterial efficiency. It is concluded that B-AuNPs have great potentials in the antibacterial researches for biocontrol, biomedicine and environmental engineering.

中文翻译：

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噬菌体样金纳米粒子的抗菌作用

病原菌的生长严重威胁人类健康。有效抑制人体内及周围环境中的病原菌，刻不容缓。在这项工作中，我们提出了一种制备用于抗菌应用的类噬菌体金纳米粒子 (B-AuNPs) 的策略。B-AuNPs 由多种方法制备原位AuNPs 表面的还原反应。结果表明，二次还原的AuNPs（B ₁ -AuNPs）具有噬菌体形状的形态。在近红外激光下，由于温度升高和活性氧（ROS）的共同作用，B _{1 -AuNPs 在低浓度下几乎可以在 5 分钟内完全抑制细菌生长。}此外，B-AuNPs 可以很容易地与死细菌分离，回收的 B-AuNPs 仍然具有很高的抗菌效率。结论是B-AuNPs在生物防治、生物医学和环境工程的抗菌研究中具有巨大的潜力。