As a new type of biomass-based molecular material, nanocrystalline cellulose (NCC) has become a research hotspot in many fields. In present work, a novel microfluidic technology was employed to produce NCC from microcrystalline cellulose (MCC) via sulfuric acid hydrolysis. The microfluidic chip was designed and made with complete load-bearing reaction according to flow characteristics. A closed reaction environment and fully automated operations can ensure the safety of experimenters. NCC (MN-60) with high yield and uniformity was obtained via acid hydrolysis in microfluidic system by 60 % sulfuric acid solution at 35 °C for 40 min. The characteristics of MN-60 and conventional method NCC (N-60) under the same reaction conditions were compared. It was found that the yield of MN-60 reached 48.13%, while it was only 17.30 % in the absence of microfluidic chip. Although the results showed that MN-60 and N-60 exhibited similar rod-like structures, the size distribution of MN-60 was narrower than that of N-60. Furthermore, the width, length, and height of MN-60 were 15 ± 5 nm, 150 ± 75 nm, and 5 ± 2 nm, respectively. The main functional groups and crystal forms of MN-60 were similar to MCC, but the crystallization index of MN-60 was higher than MCC. In conclusion, microfluidic technology could realize the preparation of high-yield and uniform NCC.

作为一种新型的生物质基分子材料，纳米晶纤维素（NCC）已成为众多领域的研究热点。在目前的工作中，采用一种新的微流体技术通过硫酸水解从微晶纤维素（MCC）生产NCC。微流控芯片根据流动特性设计制作，具有完全的承载反应。封闭的反应环境和全自动操作可以保证实验者的安全。通过在微流控系统中通过 60% 硫酸溶液在 35 °C 下酸水解 40 分钟，获得了高产率和均匀性的 NCC (MN-60)。比较了MN-60和常规方法NCC(N-60)在相同反应条件下的特性。结果发现MN-60的收率达到48.13%，而MN-60的收率仅为17。在没有微流控芯片的情况下为 30%。虽然结果表明 MN-60 和 N-60 表现出相似的棒状结构，但 MN-60 的尺寸分布比 N-60 窄。此外，MN-60 的宽度、长度和高度分别为 15 ± 5 nm、150 ± 75 nm 和 5 ± 2 nm。MN-60的主要官能团和晶型与MCC相似，但MN-60的结晶指数高于MCC。综上所述，微流控技术可以实现高产、均匀NCC的制备。MN-60的主要官能团和晶型与MCC相似，但MN-60的结晶指数高于MCC。综上所述，微流控技术可以实现高产、均匀NCC的制备。MN-60的主要官能团和晶型与MCC相似，但MN-60的结晶指数高于MCC。综上所述，微流控技术可以实现高产、均匀NCC的制备。