The simple reflective absorbance spectrophotometric smartphone device for point-of-monitoring amlodipine is presented here for the first time. The immediate analysis of amlodipine in the human urine of the patients who suffered severe side effects of this drug is very important for the diagnosis, treatment, and reduction of the death rate. This measurement technique is based on the charge-transfer complex between amlodipine and picric acid, which forms a yellow product. This product can absorb light intensity from an LED strip and measure through the Blue channel from the RGB mode with a smartphone application. The linear relationship for amlodipine monitoring was found in a wide range from 100.0 μg L⁻¹ to 140.0 mg L⁻¹ (R² = 0.999), and the limit of detection was found to be 25.0 μg L⁻¹. Our proposed method can be applied to different smartphone brands with consistent sensitivity of amlodipine detection. Additionally, the determination of amlodipine in pharmaceutical formulations and human urine samples was demonstrated by our proposed method. The recoveries were indicated in the range of 98.60 – 100.00%, which is at the acceptable level for pharmacy. This method offers an interweaving of basic technology and chemical analysis with being environmentally friendly due to reducing the complex instrument and the amount of organic waste compared to the chromatographic technique and efficient use for the detection of amlodipine. Hence, this method can be applied for prompt medical diagnoses and laboratories with limited budget resources.

用于监测点氨氯地平的简单反射吸收分光光度计智能手机设备首次在此展示。立即分析出现该药物严重副作用的患者的人尿中氨氯地平，对于诊断、治疗和降低死亡率非常重要。这种测量技术基于氨氯地平和苦味酸之间的电荷转移复合物，形成黄色产物。该产品可以从 LED 灯条吸收光强度，并使用智能手机应用程序从 RGB 模式通过蓝色通道进行测量。在从 100.0 μg L ^-1到 140.0 mg L ^-1 ( R ²= 0.999)，检测限为 25.0 μg L ^-1. 我们提出的方法可以应用于不同的智能手机品牌，具有一致的氨氯地平检测灵敏度。此外，我们提出的方法证明了对药物制剂和人尿样品中氨氯地平的测定。回收率显示在 98.60 – 100.00% 的范围内，这是药学可接受的水平。由于与色谱技术相比，该方法减少了复杂的仪器和有机废物的数量，并且有效地用于检测氨氯地平，因此该方法提供了基础技术和化学分析的交织，具有环保性。因此，该方法可用于预算资源有限的快速医学诊断和实验室。