We read with interest the article by Patel et al. on the identification of potential inhibitors of coronavirus hemagglutinin-esterase. The authors considered hemagglutinin-esterase as a glycoprotein of SARS-CoV-2 and selected hemagglutinin-esterase as a target to identify potential inhibitors using a combination of various computational approaches, and however, SARS-CoV-2 genome lacks hemagglutinin-esterase gene; thus, hemagglutinin-esterase does not exist in SARS-CoV-2 particle.

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中文翻译：

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不能将血凝素酯酶视为针对 COVID-19 设计药物的候选者

我们饶有兴趣地阅读了 Patel 等人的文章。关于冠状病毒血凝素酯酶潜在抑制剂的鉴定。作者认为血凝素酯酶是 SARS-CoV-2 的一种糖蛋白，并选择血凝素酯酶作为靶标，结合各种计算方法来识别潜在的抑制剂，然而，SARS-CoV-2 基因组缺乏血凝素酯酶基因；因此，SARS-CoV-2 颗粒中不存在血凝素酯酶。

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