Ethnic differences in intact parathyroid hormone (iPTH) at similar total 25 hydroxyvitamin D [25(OH)D] concentrations have been reported between US resident Whites, Blacks, and Hispanics, but this has not been studied between South Asians and Whites. We, therefore, compared the iPTH relationship to 25(OH)D in UK resident South Asians and Whites. A comparative, cross-sectional observational study in which demographic and laboratory data on South Asian and White residents of Wolverhampton, UK were analyzed. Log-log models measured the association between 25(OH)D and the interaction term of ethnicity and iPTH. Seven hundred and seventy-two patients consisting of 315 white subjects (208 women) and 457 South Asian subjects (331 women) were studied. Compared to South Asians, White subjects were older, had higher serum concentrations of 25(OH)D, creatinine (lower eGFR), adjusted calcium and magnesium, but similar concentrations of iPTH and phosphate. In an adjusted model, variables significantly associated with 25(OH)D included age, creatinine, adjusted calcium and ethnicity; but not iPTH and the interaction term of ethnicity and iPTH (beta coefficient –0.071, 95% CI –0.209, 0.067, p=0.32). In our study cohort, iPTH was not, per se, influenced by 25 (OH)D. We found no ethnic differences in the association between iPTH and 25(OH)D between South Asians and White UK residents

中文翻译：

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英国南亚裔和白人的完整甲状旁腺激素和 25-羟基维生素 D 之间的关系：一项比较性、横断面观察研究

据报道，美国居民白人、黑人和西班牙裔之间的完整甲状旁腺激素 (iPTH) 在相似的总 25 羟基维生素 D [25(OH)D] 浓度下存在种族差异，但尚未在南亚人和白人之间进行研究。因此，我们将 iPTH 关系与英国居民南亚人和白人的 25(OH)D 进行了比较。一项比较性横断面观察研究，其中分析了英国伍尔弗汉普顿的南亚和白人居民的人口统计和实验室数据。Log-log 模型测量了 25(OH)D 与种族和 iPTH 的交互项之间的关联。研究了 772 名患者，其中包括 315 名白人受试者（208 名女性）和 457 名南亚受试者（331 名女性）。与南亚人相比，白人受试者年龄较大，血清 25(OH)D 浓度较高，肌酐（降低 eGFR），调整钙和镁，但 iPTH 和磷酸盐的浓度相似。在调整后的模型中，与 25(OH)D 显着相关的变量包括年龄、肌酐、调整后的钙和种族；但不是 iPTH 以及种族和 iPTH 的交互项（β 系数 –0.071, 95% CI –0.209, 0.067, p=0.32）。在我们的研究队列中，iPTH 本身不受 25 (OH)D 的影响。我们发现南亚人和英国白人居民之间的 iPTH 和 25(OH)D 之间的关联没有种族差异 209, 0.067, p = 0.32)。在我们的研究队列中，iPTH 本身不受 25 (OH)D 的影响。我们发现南亚人和英国白人居民之间的 iPTH 和 25(OH)D 之间的关联没有种族差异 209, 0.067, p = 0.32)。在我们的研究队列中，iPTH 本身不受 25 (OH)D 的影响。我们发现南亚人和英国白人居民之间的 iPTH 和 25(OH)D 之间的关联没有种族差异