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Copper-mediated oxidative C−H/N−H activations with alkynes by removable hydrazides
Beilstein Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2021-07-08 , DOI: 10.3762/bjoc.17.113
Feng Xiong 1 , Bo Li 2 , Chenrui Yang 1 , Liang Zou 1 , Wenbo Ma 2 , Linghui Gu 2 , Ruhuai Mei 1, 2 , Lutz Ackermann 3
Affiliation  

The efficient copper-mediated oxidative C–H alkynylation of benzhydrazides was accomplished with terminal alkynes. Thus, a heteroaromatic removable N-2-pyridylhydrazide allowed for domino C–H/N–H functionalization. The approach featured remarkable functional group compatibility and ample substrate scope. Thereby, highly functionalized aromatic and heteroaromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C–H cleavage.

中文翻译:

铜介导的氧化 C−H/N−H 活化与炔烃通过可去除的酰肼

有效的铜介导的二苯甲酰肼氧化 C-H 炔基化反应是用末端炔烃完成的。因此,杂芳族可移除N -2-吡啶基酰肼允许多米诺 C–H/N–H 功能化。该方法具有显着的官能团兼容性和充足的底物范围。因此,高度官能化的芳香族和杂芳香族异吲哚啉-1-酮以限速的 C-H 裂解效率高。
更新日期:2021-07-08
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