Introduction: Bryophyllum pinnatum is widely used in folk medicine. It has neuropharmacological, anti-inflammatory, immunomodulatory, antidiabetic, hepatoprotective, and nephroprotective effects, among others. It also acts on uterine contractility. It is prescribed by practitioners of anthroposophic medicine for preterm labor, insomnia, and emotional disorders, and has other potential uses in obstetrics. As all drugs currently used in preterm labor have side effects, new tocolytic agents remain an area of active research. Objective: To evaluate the effect of B. pinnatum mother tincture (MT) on albino rats and their offspring throughout pregnancy from a biochemical and histological standpoint. Methods: Longitudinal, prospective, randomized controlled bioassay. This is the second stage of a trial that investigated 60 animals distributed across six equal groups: controls C1 and C2, which received 1 and 25 times the vehicle dose (30% ethanol), B1 and B2 (1- and 25-fold doses of B. pinnatum MT), and B3 and B4 (which received 50- and 100-fold doses of B. pinnatum concentrate). At this stage, blood chemistry parameters (glucose, alanine aminotransferase [ALT], aspartate aminotransferase [AST], creatinine, and blood urea nitrogen) were measured in dams, as well as histological aspects of dam liver, kidney, placenta, and uterine tissue and fetal liver, kidney, heart, and brain. Results: No differences were found between group B1 (therapeutic dose) and its control C1 in relation to glucose, AST, ALT, and creatinine. Group B2 exhibited lower glucose levels than groups C1, B3, and B4. There was no difference in AST across groups. Groups B3 and B4 exhibited higher ALT levels than groups C1 and B1. Groups B1–B4 exhibited higher urea nitrogen levels than group C1. Creatinine levels were higher in groups B2 and B3 than group C1. On morphological evaluation, fatty infiltration of the liver was observed in the alcoholic vehicle control groups (C1 and C2). Conclusions: Daily administration of B. pinnatum at therapeutic doses (group B1) to pregnant albino rats appears to be safe, with reduced glucose at dose B2, elevated ALT at doses B3 and B4, and increased urea at doses B1 to B4 and creatinine at B2 and B3, but never exceeding the normal reference range. It was not associated with histological changes in specimens of the maternal or fetal structures of interest.
Complement Med Res

中文翻译：

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苔藓植物给药对 Wistar 大鼠妊娠的影响：生化和组织学方面

简介： 苔藓植物广泛用于民间医药。它具有神经药理学、抗炎、免疫调节、抗糖尿病、保肝和肾保护等作用。它还作用于子宫收缩力。它由人智医学从业者开具治疗早产、失眠和情绪障碍的处方，并在产科中具有其他潜在用途。由于目前用于早产的所有药物都有副作用，因此新的宫缩抑制剂仍然是一个积极研究的领域。目的：从生化和组织学的角度评估B. pinnatum母酊 (MT) 对整个妊娠期白化大鼠及其后代的影响。方法：纵向、前瞻性、随机对照生物测定。这是一项试验的第二阶段，该试验研究了分布在六个相等组中的 60 只动物：对照组 C1 和 C2，它们接受了 1 和 25 倍的载体剂量（30% 乙醇），B1 和 B2（1 倍和 25 倍剂量的B. pinnatum MT），以及 B3 和 B4（接受 50 倍和 100 倍剂量的B. pinnatum浓缩物）。在这个阶段，测量了母畜的血液化学参数（葡萄糖、丙氨酸氨基转移酶 [ALT]、天冬氨酸氨基转移酶 [AST]、肌酐和血尿素氮），以及母畜肝脏、肾脏、胎盘和子宫组织的组织学方面和胎儿肝脏、肾脏、心脏和大脑。结果：B1 组（治疗剂量）与其对照 C1 组之间在葡萄糖、AST、ALT 和肌酐方面没有发现差异。B2 组的血糖水平低于 C1、B3 和 B4 组。各组之间的 AST 没有差异。B3 和 B4 组表现出比 C1 和 B1 组更高的 ALT 水平。B1-B4 组的尿素氮水平高于 C1 组。B2和B3组的肌酐水平高于C1组。在形态学评估中，在酒精载体对照组（C1 和 C2）中观察到肝脏的脂肪浸润。结论：每日施用B. pinnatum治疗剂量（B1 组）对怀孕白化病大鼠似乎是安全的，剂量 B2 葡萄糖降低，剂量 B3 和 B4 升高 ALT，剂量 B1 至 B4 尿素和 B2 和 B3 肌酐升高，但从未超过正常参考范围。它与感兴趣的母体或胎儿结构标本的组织学变化无关。
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