There are only 13 cases of complete remission after sorafenib use in advanced hepatocellular carcinoma (HCC) worldwide. We herein report a rarer case in which the patient was cured after only 20 days of sorafenib use. A 61-year-old male patient was diagnosed with a huge HCC. The mass occupied almost the whole of the right hepatic lobe and a portion of segment 4. We performed extended right hepatectomy for cure. However, 3.5-cm-sized subcarinal lymph node metastasis was detected at 15 months after operation. We prescribed sorafenib 400 mg bid for palliative treatment. The patient had severe fever, pain, and blisters on the hands and feet, so the patient stopped taking it after 20 days. Subcarinal lymph node disappeared on chest computed tomography after 3 months, and there was no evidence of recurrence for a year.
Case Rep Gastroenterol 2021;15:610–615

中文翻译：

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20 天索拉非尼治疗治愈远处转移的肝细胞癌

全球仅有 13 例使用索拉非尼治疗晚期肝细胞癌（HCC）后完全缓解。我们在此报告了一个罕见的病例，该病例仅使用索拉非尼 20 天就治愈了患者。一名 61 岁的男性患者被诊断出患有巨大的 HCC。肿块几乎占据了整个右肝叶和部分第 4 节段。我们进行了扩大的右肝切除术以治愈。然而，术后15个月检测到3.5cm大小的隆突下淋巴结转移。我们为姑息治疗开了索拉非尼 400 mg 每天两次。患者发热剧烈，疼痛，手脚出现水泡，20天后停药。3 个月后，胸部 CT 显示隆突下淋巴结消失，一年内无复发迹象。
Case Rep Gastroenterol 2021；15:610–615