Abstract

The results of studies performed at the Khlopin Radium Institute in cooperation with other institutions from Russia and other countries, and also published data in the field of chemistry of higher technetium carbonyl compounds are summarized in the context of problems of nuclear medicine. Chemical problems that arise on the way of using higher technetium carbonyls in nuclear medicine and are associated with the synthesis conditions and reactivity of these complexes, and also the ways to solve these problems are analyzed. The major problems are the need for using high pressures in synthesis, the impossibility of direct replacement of halogen in pentacarbonyl halides (products directly obtained from pertechnetate ion) by other monodentate ligands, limited resistance of many higher technetium carbonyls to decarbonylation, and susceptibility of higher technetium carbonyls to nucleophilic reactions (including hydrolysis in alkaline media). The latter problem seems to be the most critical. The scientific outcome of the studies is outlined, and comparison with rhenium analogs is made. The complex [^99mTcI(CO)₅] shows promise for lung imaging; assumptions concerning the mechanism of its lung uptake are formulated.

中文翻译：

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高锝（I）羰基化合物及其在核医学中使用的可能性：问题与前景

摘要

科洛平镭研究所与俄罗斯和其他国家的其他机构合作进行的研究结果，以及在高锝羰基化合物化学领域发表的数据，都在核医学问题的背景下进行了总结。分析了在核医学中使用高锝羰基化合物的过程中出现的与这些配合物的合成条件和反应活性有关的化学问题，以及解决这些问题的方法。主要问题是在合成中需要使用高压，不可能用其他单齿配体直接替代五羰基卤化物（从高锝酸盐离子直接获得的产物）中的卤素，许多高级羰基锝对脱羰的抵抗力有限，以及高级羰基锝对亲核反应（包括在碱性介质中的水解）的敏感性。后一个问题似乎是最关键的。概述了研究的科学成果，并与铼类似物进行了比较。复杂的 [^99m TcI(CO) ₅ ] 显示出肺成像的前景；制定了有关其肺摄取机制的假设。