Abstract

Zirconium-89 is a promising radionuclide for nuclear medicine and has optimal nuclear-physical parameters for study of processes with slow kinetic. The increasing popularity of targeted imaging has led to a concomitant development of ⁸⁹Zr radiopharmaceutical chemistry. At present, a tremendous amount of scientific work has been carried out in all fields: from production of ⁸⁹Zr at accelerators to clinical studies of different radiopharmaceuticals. The review contains a description and comparison of various methods for preparation, extraction, and purification of ⁸⁹Zr, and discusses the most common chemical forms used in the synthesis of the complexes.

中文翻译：

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放射性药物合成用 89Zr 溶液的制备

摘要

锆 89 是一种很有前途的核医学放射性核素，具有最佳的核物理参数，可用于研究慢动力学过程。靶向成像的日益普及导致了⁸⁹ Zr 放射性药物化学的伴随发展。目前，已经在各个领域开展了大量的科学工作：从在加速器中生产⁸⁹ Zr 到不同放射性药物的临床研究。该综述包含对⁸⁹ Zr的各种制备、提取和纯化方法的描述和比较，并讨论了配合物合成中最常见的化学形式。