ABSTRACT

Background

Because of the higher risk of drug use, especially benzodiazepines, treating sleep disorders in patients, undergoing Methadone Maintenance Therapy, is one of the daily challenges of addiction therapists. Pregabalin is an antiepileptic drug that is used for insomnia and neuropathic pain. It seems that pregabalin has a lower risk of dependency than benzodiazepines.

Methods

A total of 107 patients participated in this study. Participants randomly assigned to intervention and control groups. The intervention group received 75 mg of pregabalin and the control group received placebo over 8 weeks. The main instruments of the study were the Pittsburgh Sleep Quality Index (PSQI) and Demographic Questionnaire to collect data on the sleep quality of the MMT patients.

Results

Sleep duration and sleep efficiency significantly improved in the pregabalin group compared to the placebo group but in other scales of sleep quality, no significant difference is found between the two groups.

Conclusion

The current study used a low dose of pregabalin for treating sleep disturbances in patients being treated with methadone, however; it is suggested that future studies may use higher doses of pregabalin (e.g., 150 and 300 mg) for enhancing the different components of sleep quality as well as overall sleep quality.

中文翻译：

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普瑞巴林对美沙酮维持治疗患者睡眠质量的影响：一项双盲随机临床试验

摘要

背景

由于药物使用的风险较高，尤其是苯二氮卓类药物，治疗患者的睡眠障碍，接受美沙酮维持治疗，是成瘾治疗师的日常挑战之一。普瑞巴林是一种抗癫痫药物，用于失眠和神经性疼痛。似乎普瑞巴林的依赖风险低于苯二氮卓类药物。

方法

共有 107 名患者参加了这项研究。参与者被随机分配到干预组和对照组。干预组接受 75 mg 普瑞巴林，对照组接受安慰剂超过 8 周。该研究的主要工具是匹兹堡睡眠质量指数（PSQI）和人口统计问卷，以收集有关 MMT 患者睡眠质量的数据。

结果

与安慰剂组相比，普瑞巴林组的睡眠时间和睡眠效率显着改善，但在其他睡眠质量量表中，两组之间没有显着差异。

结论

然而，目前的研究使用低剂量的普瑞巴林来治疗接受美沙酮治疗的患者的睡眠障碍；建议未来的研究可能使用更高剂量的普瑞巴林（例如，150 和 300 毫克）来提高睡眠质量的不同组成部分以及整体睡眠质量。