Inflammatory bowel disease (IBD) is characterised by dysregulated mucosal immune responses associated with genetic, environmental and microbial factors. Recent therapies targeting key inflammatory mediators such as tumor necrosis factor (TNF)-α emphasise the importance of innate immunity in the development of IBD.

中文翻译：

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肠黏膜中产生 GM-CSF 的 NCR-ILC3 和中性粒细胞增加会加剧炎症性肠病

炎症性肠病 (IBD) 的特征是与遗传、环境和微生物因素相关的粘膜免疫反应失调。最近针对关键炎症介质如肿瘤坏死因子 (TNF)-α 的疗法强调了先天免疫在 IBD 发展中的重要性。