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Apoptotic cell signals and heterogeneity in macrophage function: Fine-tuning for a healthy liver
Seminars in Cell & Developmental Biology ( IF 7.3 ) Pub Date : 2021-07-08 , DOI: 10.1016/j.semcdb.2021.06.012
Imke Liebold 1 , Amirah Al Jawazneh 1 , Madeleine Hamley 1 , Lidia Bosurgi 1
Affiliation  

Functional heterogeneity in tissue macrophage populations has often been traced to developmental and spatial cues. Upon tissue damage, macrophages are exposed to soluble mediators secreted by activated cells, which shape their polarisation. Interestingly, macrophages are concomitantly exposed to a variety of different dying cells, which carry miscellaneous signals and that need to be recognised and promptly up-taken by professional phagocytes. This review discusses how differences in the nature of the dying cells, like their morphological and biochemical features as well as the specificity of phagocytic receptor usage on macrophages, might contribute to the transcriptional and functional heterogeneity observed in phagocytic cells in the tissue.



中文翻译:

巨噬细胞功能的凋亡细胞信号和异质性:健康肝脏的微调

组织巨噬细胞群的功能异质性通常可以追溯到发育和空间线索。在组织损伤后,巨噬细胞暴露于活化细胞分泌的可溶性介质,从而形成它们的极化。有趣的是,巨噬细胞同时暴露于各种不同的垂死细胞,这些细胞携带各种信号,需要被专业吞噬细胞识别并迅速吸收。这篇综述讨论了垂死细胞性质的差异,如它们的形态和生化特征以及巨噬细胞上吞噬受体使用的特异性,可能如何促成在组织中的吞噬细胞中观察到的转录和功能异质性。

更新日期:2021-07-08
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