Preparation of resin spheres with high monodispersity and controllable size is of significant value for the research and development of functional composite particles applicable to energy exploitations, biomedical technologies and micro−/nanofluidic devices. Unfortunately, traditional bulk synthesis for resin spheres suffers from some drawbacks including inaccurate control over flow and reaction conditions, high requirements on equipment and operation, and sometimes hazardous to operators and environment. In this paper, a microfluidic platform assembled with separated charging inlets, winding channel and helical tube structure is designed for the controllable synthesis of small sized and monodispersed 3-aminophenol formaldehyde resin spheres. The optimal operating conditions are found with the flow rates of 200 μL/min for continuous phase and 15 μL/min for each reagent flow, and the residence time of 270 s and temperature of 80 °C in the water-bath. The obtained resin particles show regular spherical shapes and have a small size of around 250 nm with high monodispersity (polydispersity index <4%). The present microfluidic platform not only provides a promising substitution to traditional bulk synthesis but also allows for the accurate regulations of particle size and monodispersity.

制备具有高单分散性和可控尺寸的树脂球对于适用于能源开发、生物医学技术和微/纳米流体装置的功能复合颗粒的研究和开发具有重要价值。不幸的是，传统的树脂球本体合成存在一些缺点，包括对流动和反应条件的控制不准确，对设备和操作的要求高，有时对操作者和环境有害。在本文中，设计了一个由分离的充电入口、缠绕通道和螺旋管结构组装而成的微流体平台，用于可控合成小尺寸和单分散的 3-氨基苯酚甲醛树脂球体。最佳操作条件是连续相流速为 200 μL/min，每个试剂流为 15 μL/min，在水浴中停留时间为 270 s，温度为 80 °C。所得树脂颗粒呈规则的球形，粒径小，约为250 nm，单分散性高（多分散指数<4%）。目前的微流体平台不仅提供了对传统批量合成的有希望的替代，而且还允许准确调节粒径和单分散性。