The synergistic nanotheranostics of reactive oxygen species (ROS) augment or phototherapy has been a promising method within synergistic oncotherapy. However, it is still hindered by sophisticated design and fabrication, lack of a multimodal synergistic effect, and hypoxia-associated poor photodynamic therapy (PDT) efficacy. Herein, a kind of porous shuttle-shape platinum (IV) methylene blue (Mb) coordination polymer nanotheranostics-loaded 10-hydroxycamptothecin (CPT) is fabricated to address the abovementioned limitations. Our nanoreactors possess spatiotemporally controlled O₂ self-supply, self-sufficient singlet oxygen (¹O₂), and outstanding photothermal effect. Once they are taken up by tumor cells, nanoreactors as a cascade catalyst can efficiently catalyze degradation of the endogenous hydrogen peroxide (H₂O₂) into O₂ to alleviate tumor hypoxia. The production of O₂ can ensure enhanced PDT. Subsequently, under both stimuli of external red light irradiation and internal lysosomal acidity, nanoreactors can achieve the on-demand release of CPT to augment in situ mitochondrial ROS and highly efficient tumor ablation via phototherapy. Moreover, under the guidance of near-infrared (NIR) fluorescent imaging, our nanoreactors exhibit strongly synergistic potency for treatment of hypoxic tumors while reducing damages against normal tissues and organs. Collectively, shuttle-shape platinum-coordinated nanoreactors with augmented ROS capacity and enhanced phototherapy efficiency can be regarded as a novel tumor theranostic agent and further promote the research of synergistic oncotherapy.

中文翻译：

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具有 O2 自供和 ROS 增强的梭形无载体铂配位纳米反应器用于增强缺氧肿瘤的光疗

活性氧 (ROS) 增强或光疗的协同纳米治疗学一直是协同肿瘤治疗中一种很有前途的方法。然而，它仍然受到复杂的设计和制造、缺乏多模式协同效应以及缺氧相关的光动力疗法 (PDT) 效果不佳的阻碍。在此，制备了一种多孔梭形铂 (IV) 亚甲蓝 (Mb) 配位聚合物纳米治疗学负载 10-羟基喜树碱 (CPT) 以解决上述局限性。我们的纳米反应器具有时空控制的 O ₂自供、自给单线态氧 ( ¹ O ₂)，以及出色的光热效应。一旦它们被肿瘤细胞吸收，纳米反应器作为级联催化剂可以有效地催化内源性过氧化氢（H ₂ O ₂）降解为O ₂以缓解肿瘤缺氧。O _{2 的产生}可以确保增强的PDT。随后，在外部红光照射和内部溶酶体酸度的刺激下，纳米反应器可以实现 CPT 的按需释放以增强原位线粒体 ROS 和通过光疗高效消融肿瘤。此外，在近红外（NIR）荧光成像的指导下，我们的纳米反应器在治疗缺氧肿瘤的同时减少对正常组织和器官的损伤表现出强烈的协同作用。总的来说，具有增强ROS能力和增强光疗效率的梭形铂配位纳米反应器可被视为一种新型肿瘤治疗剂，并进一步促进协同肿瘤治疗的研究。