In this work, we introduced a multifunctional Ag(I)/CAAA-amidphos complex catalyzed asymmetric 1,3-dipolar cycloaddition of acrylates with α-imino esters, affording a series of 2,4,5-trisubstituted endo-pyrrolidines in good yields (up to 97%) with high enantioselectivities (up to 98% ee). Meanwhile, the catalytic system was also applied in the three-component one-pot reaction of α-imino esters formed in situ under the action of N,N′-diisopropylcarbodiimide. In addition, the gram-scale reaction was realized for the formal synthesis of (+)-ibophyllidine in eight steps.

中文翻译：

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Ag(I)/CAAA-Amidphos 复合物催化丙烯酸酯的不对称 1,3-偶极环加成反应以正式合成 (+)-异叶酸

在这项工作中，我们引入了一种多功能的 Ag(I)/CAAA-酰胺磷配合物催化丙烯酸酯与 α-亚氨基酯的不对称 1,3-偶极环加成反应，以良好的收率提供了一系列 2,4,5-三取代的内-吡咯烷（高达 97%）具有高对映选择性（高达 98% ee）。同时，该催化体系也应用于N,N'-二异丙基碳二亚胺作用下原位生成的α-亚氨基酯的三组分一锅反应。此外，在八步中实现了（+）-异叶酸的正式合成的克级反应。