A novel angucyclinone, 6,9-dihydroxytetrangulol, was isolated from Streptomyces lividans TK23 transformed with a kinanthraquinone biosynthetic gene cluster in which the kiqO gene was disrupted. The chemical structure was elucidated by spectroscopic analyses. It showed significant antibacterial activities with an IC₅₀ value of 1.9 μM against Staphylococcus aureus and moderate anticancer activities against HL-60 cells.

中文翻译：

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6,9-Dihydroxytetrangulol，一种新型 angucyclinone 抗生素在 kinanthraquinone 的生物合成中积累在 kiqO 基因破坏剂中

从链霉菌TK23中分离出一种新型 angucyclinone，6,9-dihydroxytetrangulol，该链霉菌使用 kinanthraquinone 生物合成基因簇进行转化，其中kiqO基因被破坏。通过光谱分析阐明了化学结构。它显示出显着的抗菌活性，对金黄色葡萄球菌的 IC ₅₀值为 1.9 μM，对 HL-60 细胞具有中等的抗癌活性。