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A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study
Cardiovascular Diabetology ( IF 9.3 ) Pub Date : 2021-07-07 , DOI: 10.1186/s12933-021-01328-0
Amy S Shah 1 , Scott Isom 2 , Dana Dabelea 3 , Ralph D'Agostino 2 , Lawrence M Dolan 1 , Lynne Wagenknecht 2 , Giuseppina Imperatore 4 , Sharon Saydah 4 , Angela D Liese 5 , Jean M Lawrence 6 , Cate Pihoker 7 , Elaine M Urbina 1 ,
Affiliation  

To compare left ventricular structure (LV) and diastolic function in young adults with youth- onset diabetes by type, determine the prevalence of abnormal diastolic function by diabetes type using published values from age similar healthy controls, and examine the risk factors associated with diastolic function. In a cross sectional analysis we compared LV structure and diastolic function from two dimensional echocardiogram in participants with type 1 (T1D) and type 2 diabetes (T2D) who participated in the SEARCH for Diabetes in Youth Study. Linear models were used to examine the risk factors associated with worse diastolic function. Of 479 participants studied, 258 had T1D (mean age 21.2 ± 5.2 years, 60.5% non-Hispanic white, 53.9% female) and 221 had T2D (mean age 24.8 ± 4.3 years, 24.4% non-Hispanic white, 73.8% female). Median diabetes duration was 11.6 years. Participants with T2D had greater LV mass index and worse diastolic function that persisted after adjustment for differences in risk factors compared with participants with T1D (all p < 0.05). Abnormal diastolic function, quantified using healthy controls, was pronounced in both groups but greater in those with T2D than T1D (T2D: 57.7% vs T1D: 47.2%, respectively), p < 0.05. Risk factors associated with worse diastolic function included older age at diabetes diagnosis, female sex, higher BP, heart rate and HbA1c and longer diabetes duration. LV structure and diastolic function is worse in individuals with T2D compared to T1D. However, abnormal diastolic function in seen in both groups compared to published values from age similar healthy controls.

中文翻译:

一项横断面研究,比较青少年和年轻成人 1 型和 2 型糖尿病患者的心脏结构和舒张功能:青少年糖尿病研究

为了按类型比较青年发病糖尿病患者的左心室结构 (LV) 和舒张功能,使用来自年龄相似的健康对照的公布值确定不同糖尿病类型的舒张功能异常的发生率,并检查与舒张功能相关的危险因素. 在横断面分析中,我们比较了参加青少年糖尿病研究的 1 型 (T1D) 和 2 型糖尿病 (T2D) 参与者的二维超声心动图的 LV 结构和舒张功能。线性模型用于检查与舒张功能恶化相关的风险因素。在研究的 479 名参与者中,258 人患有 T1D(平均年龄 21.2 ± 5.2 岁,60.5% 非西班牙裔白人,53.9% 女性)和 221 人患有 T2D(平均年龄 24.8 ± 4.3 岁,24.4% 非西班牙裔白人,73.8% 女性) . 中位糖尿病病程为 11.6 年。与 T1D 参与者相比,T2D 参与者具有更大的 LV 质量指数和更差的舒张功能,在调整风险因素差异后持续存在(所有 p < 0.05)。使用健康对照量化的异常舒张功能在两组中均显着,但在 T2D 患者中比在 T1D 患者中更明显(T2D:57.7% 对 T1D:47.2%,分别),p < 0.05。与舒张功能较差相关的风险因素包括糖尿病诊断年龄较大、女性、较高的血压、心率和 HbA1c 以及较长的糖尿病病程。与 T1D 相比,T2D 患者的 LV 结构和舒张功能更差。然而,与年龄相似的健康对照组的公布值相比,两组的舒张功能异常。与 T1D 参与者相比,T2D 参与者具有更大的 LV 质量指数和更差的舒张功能,在调整风险因素差异后持续存在(所有 p < 0.05)。使用健康对照量化的异常舒张功能在两组中均显着,但在 T2D 患者中比在 T1D 患者中更明显(T2D:57.7% 对 T1D:47.2%,分别),p < 0.05。与舒张功能较差相关的风险因素包括糖尿病诊断年龄较大、女性、较高的血压、心率和 HbA1c 以及较长的糖尿病病程。与 T1D 相比,T2D 患者的 LV 结构和舒张功能更差。然而,与年龄相似的健康对照组的公布值相比,两组的舒张功能异常。与 T1D 参与者相比,T2D 参与者具有更大的 LV 质量指数和更差的舒张功能,在调整风险因素差异后持续存在(所有 p < 0.05)。使用健康对照量化的异常舒张功能在两组中均显着,但在 T2D 患者中比在 T1D 患者中更明显(T2D:57.7% 对 T1D:47.2%,分别),p < 0.05。与舒张功能较差相关的风险因素包括糖尿病诊断年龄较大、女性、较高的血压、心率和 HbA1c 以及较长的糖尿病病程。与 T1D 相比,T2D 患者的 LV 结构和舒张功能更差。然而,与年龄相似的健康对照组的公布值相比,两组的舒张功能异常。
更新日期:2021-07-07
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