Homologous recombination (HR) is a universal phenomenon conserved from viruses to humans. The mechanisms of HR are essentially the same in humans and simple unicellular eukaryotes like yeast. Two highly diverged yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe, have proven exceptionally useful in understanding the fundamental mechanisms of eukaryotic HR by serving as a source for unique biological insights and also complementing each other. Here, we will review the features of S. pombe HR mechanisms in comparison to S. cerevisiae and other model organisms. Particular emphasis will be put on the biochemical characterization of HR mechanisms uncovered using S. pombe proteins.

同源重组（HR）是从病毒到人类的普遍现象。HR的机制在人类和酵母等简单的单细胞真核生物中基本相同。事实证明，两种高度分化的酵母物种，酿酒酵母和粟酒裂殖酵母，通过作为独特生物学见解的来源并相互补充，在理解真核 HR 的基本机制方面非常有用。在这里，我们将回顾S. pombe HR 机制与S. cerevisiae和其他模式生物相比的特征。将特别强调使用S. pombe蛋白揭示的 HR 机制的生化特征。