Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study,Clinical and Experimental Hypertension

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Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study
Clinical and Experimental Hypertension ( IF 12.3 ) Pub Date : 2021-07-06 , DOI: 10.1080/10641963.2021.1925681
Masato Takase ₁ , Tomohiro Nakamura _{1,

2} , Naho Tsuchiya _{1,

2} , Mana Kogure _{1,

2} , Fumi Itabashi _{1,

2} , Akira Narita _{1,

2} , Takumi Hirata _{2,

3} , Naoki Nakaya _{2,

4} , Yohei Hamanaka ₅ , Junichi Sugawara _{1,

6,

7} , Kichiya Suzuki ₈ , Nobuo Fuse _{5,

9} , Akira Uruno ₅ , Eiichi N Kodama _{1,

10} , Shinichi Kuriyama _{1,

2,

11} , Ichiro Tsuji _{1,

2} , Shigeo Kure _{1,

2,

12} , Atsushi Hozawa _{1,

2}

Affiliation

Graduate School of Medicine, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of Public Health, Hokkaido University Faculty of Medicine, Kita-ku, Sapporo, Hokkaido, Japan.
Department of Health Sciences, Saitama Prefectural University, Koshigaya, Saitama, Japan.
Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of Feto-Maternal Medical Science, Tohoku University Hospital, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of Biobank,Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of Public Relations and planning, Tohoku Medical Megabank Organization, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of Infection Disease, International Research Institute of Disaster Science, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of wct 2Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Department of pediatrics, Tohoku University Hospital, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.

ABSTRACT

Background

A higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension.

Methods

We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension.

Results

Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant.

Conclusions

Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.

中文翻译：

综合脂肪量和无脂肪质量指数与高血压之间的关联：东北医疗 Megabank 社区队列研究

摘要

背景

较高的体脂百分比与高血压有关，即使在非肥胖个体中也是如此。身体成分的差异可能与高血压有关。脂肪质量指数 (FMI) 和无脂肪质量指数 (FFMI) 是建议的身体成分指标。本研究旨在检查 FMI 和 FFMI 组合与高血压的关系。

方法

我们对日本东北部宫城县的 5,058 名男性和 11,842 名年龄≥20 岁的女性进行了横断面研究。FMI 和 FFMI 分别计算为脂肪量和无脂肪量除以身高的平方。将这些指标分为四分位数并合并为 16 组。高血压定义为偶然血压≥ 140/90 mmHg 和/或自我报告的高血压治疗。使用针对潜在混杂因素进行调整的多变量逻辑回归模型来评估 FMI 和 FFMI 组合与高血压的关系。