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Optical manipulation: advances for biophotonics in the 21st century
Journal of Biomedical Optics ( IF 3.5 ) Pub Date : 2021-07-01 , DOI: 10.1117/1.jbo.26.7.070602
Stella Corsetti 1 , Kishan Dholakia 2, 3, 4
Affiliation  

Significance: Optical trapping is a technique capable of applying minute forces that has been applied to studies spanning single molecules up to microorganisms. Aim: The goal of this perspective is to highlight some of the main advances in the last decade in this field that are pertinent for a biomedical audience. Approach: First, the direct determination of forces in optical tweezers and the combination of optical and acoustic traps, which allows studies across different length scales, are discussed. Then, a review of the progress made in the direct trapping of both single-molecules, and even single-viruses, and single cells with optical forces is outlined. Lastly, future directions for this methodology in biophotonics are discussed. Results: In the 21st century, optical manipulation has expanded its unique capabilities, enabling not only a more detailed study of single molecules and single cells but also of more complex living systems, giving us further insights into important biological activities. Conclusions: Optical forces have played a large role in the biomedical landscape leading to exceptional new biological breakthroughs. The continuous advances in the world of optical trapping will certainly lead to further exploitation, including exciting in-vivo experiments.

中文翻译:

光学操纵:21世纪生物光子学的进展

意义:光捕获是一种能够施加微小力的技术,已应用于从单分子到微生物的研究。目的:这一观点的目的是突出过去十年该领域的一些主要进展,这些进展与生物医学受众相关。方法:首先,讨论了光镊中力的直接测定以及光学和声学陷阱的组合,这允许在不同长度尺度上进行研究。然后,概述了在直接捕获单分子甚至单病毒以及具有光学力的单细胞方面取得的进展。最后,讨论了这种方法在生物光子学中的未来方向。结果:在 21 世纪,光学操纵扩展了其独特的能力,不仅可以对单分子和单细胞进行更详细的研究,还可以对更复杂的生命系统进行更详细的研究,从而使我们对重要的生物活动有了进一步的了解。结论:光学力量在生物医学领域发挥了重要作用,导致了非凡的新生物学突破。光捕获领域的不断进步肯定会导致进一步的开发,包括令人兴奋的体内实验。
更新日期:2021-07-07
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