Objective To evaluate whether topical therapy is linked to scores related to anxiety, depression and quality of life (QoL) in inflammatory eye disease (IED). Methods and analysis Patients with ocular surface disease (OSD, N=100) and Uveitis (N=100) completed self-administered validated questions on ocular symptoms and well-being, with supplemental questions on eye drop frequency. Results Forty (20%) patients had scores consistent with depression and 33 (17%) anxiety. Anxiety, depression, QoL and OSD index (OSDI) scores did not differ significantly between OSD and Uveitis groups. In those with anxiety or depression, QoL was significantly reduced in all WHO Quality Of Life-BREF domains (all p<0.001). Multivariable analysis considering demographic and disease-related factors found daily topical drop frequency to be independently associated with anxiety (p=0.009) but not depression (p=0.300). Conclusion A high proportion of patients with IED demonstrated scores indicative of anxiety and depression. Preliminary evidence suggests that the frequency of topical eye drops potentially plays a significant role in the psychological health status of patients with IED . Data are available upon request;

中文翻译：

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炎症性眼病中的焦虑和抑郁：探索局部治疗频率作为推定的心理测量项目的潜在影响

目的 评估局部治疗是否与炎症性眼病 (IED) 中焦虑、抑郁和生活质量 (QoL) 相关的评分相关。方法和分析 眼表疾病（OSD，N = 100）和葡萄膜炎（N = 100）患者完成了关于眼部症状和健康的自我管理验证问题，以及关于滴眼频率的补充问题。结果 40 名 (20%) 患者的得分与抑郁症和 33 名 (17%) 焦虑症一致。OSD 组和葡萄膜炎组之间的焦虑、抑郁、生活质量和 OSD 指数 (OSDI) 评分没有显着差异。在焦虑或抑郁患者中，所有 WHO 生活质量-BREF 领域的 QoL 均显着降低（所有 p<0.001）。考虑到人口统计学和疾病相关因素的多变量分析发现，每日局部用药频率与焦虑（p=0.009）独立相关，但与抑郁无关（p=0.300）。结论 高比例的 IED 患者表现出焦虑和抑郁的评分。初步证据表明，局部滴眼液的频率可能对 IED 患者的心理健康状况起重要作用。数据可应要求提供；