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Three ‘D’s: Design approach, dimensional printing, and drug delivery systems as promising tools in healthcare applications
Drug Discovery Today ( IF 7.4 ) Pub Date : 2021-07-06 , DOI: 10.1016/j.drudis.2021.06.016
Mahfoozur Rahman 1 , Waleed H Almalki 2 , Saad Alghamdi 3 , Khalid S Alharbi 4 , Habibullah Khalilullah 5 , Md Habban Akhter 6 , Amit K Keshari 6 , Nisha Sharma 6 , Tanuja Singh 7 , Kriti Soni 8 , Abdul Hafeez 9 , Sarwar Beg 10
Affiliation  

The development of pharmaceutical drug products is required for the treatment of disease, which has resulted in an increasing number of approvals by regulatory agencies across the globe. To establish a hassle-free manufacturing process, the systematic use of a quality-by-design (QbD) approach combined with process analytical technology (PAT) and printing techniques can revolutionize healthcare applications. Printing technology has been emerged in various dimensions, such as 3D, 4D, and 5D printing, with respect to their production capabilities, durability, and accuracy of pharmaceutical manufacturing, which can efficiently deliver novel patient-centric healthcare products with holistic characteristics. In this review, we provide current trends in pharmaceutical product development using a design approach and high-quality printing techniques.



中文翻译:

三个“D”:设计方法、三维打印和药物输送系统作为医疗保健应用中的有前途的工具

药物产品的开发是治疗疾病所必需的,这导致全球监管机构的批准数量不断增加。为了建立无忧的制造流程,系统地使用质量源于设计 (QbD) 的方法与过程分析技术 (PAT) 和印刷技术相结合,可以彻底改变医疗保健应用。3D、4D、5D打印等打印技术在药品制造的生产能力、耐用性和准确性方面已经出现,可以有效地提供具有整体特征的新型以患者为中心的医疗保健产品。在这篇评论中,我们提供了使用设计方法和高质量印刷技术的医药产品开发的当前趋势。

更新日期:2021-07-06
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