The WEE1 G2 checkpoint kinase acts as a negative cell cycle regulator for entry into mitosis (G2-to-M transition). This comment extends a recent Advanced Science paper by reporting higher WEE1-dependency of triple negative breast cancer (TNBC) cell lines, pejorative prognostic value of WEE1 expression in TNBC clinical samples as well as higher expression of biomarkers of sensitivity to WEE1 inhibitor.

中文翻译：

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三阴性乳腺癌中的 WEE1 依赖性和不良预后价值

WEE1 G2 检查点激酶充当进入有丝分裂（G2 到 M 转变）的负细胞周期调节剂。此评论扩展了最近发表的《Advanced Science》论文，报告了三阴性乳腺癌 (TNBC) 细胞系对 WEE1 的更高依赖性、 TNBC 临床样本中WEE1表达的贬义预后价值以及对 WEE1 抑制剂敏感的生物标志物的更高表达。