Lipids on the plasma membrane are not only components of the membrane biophysical structures but also regulators of receptor functions. Recently, the critical roles of lipid-protein interactions have been intensively highlighted. Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate. Here, we review recent findings on how direct interaction with these lipids regulates EGFR activation and signaling, providing unprecedented insight into the comprehensive roles of various lipids in the control of EGFR functions. Finally, the current limitations in investigating lipid-protein interactions and novel technologies to potentially overcome these limitations are discussed.

质膜上的脂质不仅是膜生物物理结构的组成部分，也是受体功能的调节剂。最近，脂质-蛋白质相互作用的关键作用得到了广泛的强调。表皮生长因子受体 (EGFR) 是研究最广泛的受体之一，表现出各种脂质相互作用，包括与磷脂酰胆碱、磷脂酰丝氨酸、磷酸磷脂酰肌醇、胆固醇、神经节苷脂和棕榈酸酯的相互作用。在这里，我们回顾了最近关于与这些脂质的直接相互作用如何调节 EGFR 激活和信号传导的发现，为各种脂质在控制 EGFR 功能中的综合作用提供了前所未有的见解。最后，