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Sestrin2 in hypoxia and hypoxia-related diseases
Redox Report ( IF 3.8 ) Pub Date : 2021-07-05 , DOI: 10.1080/13510002.2021.1948774
Xiaojing Che 1, 2 , Jiagui Chai 1, 2 , Yan Fang 1 , Xifeng Zhang 1 , Anju Zu 1 , Lin Li 1 , Shibo Sun 1, 3 , Weimin Yang 3
Affiliation  

ABSTRACT

Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.

Methods: A review was conducted through an electronic search of PubMed and Medline databases. Keywords included Sestrin2, ROS, hypoxia, and hypoxia-related disease. Articles from 2008 to 2021 were mostly included and older ones were not excluded.

Results: Sestrin2 is upregulated under various stress conditions, especially hypoxia. Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway. In addition, Sestrin2 is involved in various hypoxia-related diseases, such as cerebral hypoxic disease, myocardial hypoxic disease, hypoxia-related respiratory disease, and diabetes.

Discussion: Sestrin2 is involved in various hypoxia-related diseases and maybe a therapeutic target. Furthermore, most studies focus on cerebral and myocardial ischemia reperfusion. More researches on hypoxia-related respiratory diseases, kidney injury, and diabetes are needed in future.



中文翻译:

Sestrin2 在缺氧和缺氧相关疾病中的作用

摘要

目的: Sestrin2是一种应激诱导蛋白,在细胞适应应激状态中起重要作用。本文综述了Sestrin2在缺氧及缺氧相关疾病中的作用,为未来研究提供新视角,为缺氧相关疾病提供新的治疗靶点。

方法:通过对 PubMed 和 Medline 数据库的电子搜索进行审查。关键词包括Sestrin2、ROS、缺氧和缺氧相关疾病。2008 年至 2021 年的文章大多被包括在内,不排除较旧的文章。

结果: Sestrin2 在各种应激条件下上调,尤其是在缺氧条件下。在缺氧条件下,Sestrin2 通过多种途径减少 ROS 的产生而发挥保护作用,如单磷酸腺苷激活蛋白激酶 (AMPK)/哺乳动物雷帕霉素靶蛋白 (mTOR) 途径和核因子-E2 相关因子 2 (Nrf2)途径。此外,Sestrin2参与多种缺氧相关疾病,如脑缺氧病、心肌缺氧病、缺氧相关呼吸系统疾病、糖尿病等。

讨论: Sestrin2 参与多种缺氧相关疾病,可能是治疗靶点。此外,大多数研究集中于脑和心肌缺血再灌注。未来需要对缺氧相关的呼吸系统疾病、肾损伤和糖尿病进行更多的研究。

更新日期:2021-07-06
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