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A new N-oxide benzylisoquinoline alkaloid isolated from the leaves of atemoya (Annona cherimola × Annona squamosa)
Zeitschrift für Naturforschung B ( IF 0.8 ) Pub Date : 2021-07-01 , DOI: 10.1515/znb-2020-0187
Suzana V. Rabêlo 1 , Edigênia C. C. Araújo 2 , Emmanoel V. Costa 3 , Raimundo Braz-Filho 4, 5 , Andersson Barison 6 , Maria de F. C. Santos 7 , Gibson G. Oliveira 8 , José C. Tomaz 8 , Larissa A. Rolim 1, 2 , Norberto P. Lopes 8 , Maria F. S. Silva 9 , Manoel O. Moraes 9 , Cláudia do Ó Pessoa 9 , Noureddine El Aouad 10 , Jackson R. G. S. Almeida 1, 2
Affiliation  

Phytochemical investigation of the atemoya aerial parts was carried out by LC-MS-IT and cytotoxic activities were evaluated as well. These results led to the identification of a new N -oxide alkaloid (dehydroanomuricine- N -oxide) and eight other alkaloids: scoulerine, reticuline, isocorydine, norisocorydine, asimilobine, nornuciferine, anonaine, and liriodenine. The new alkaloid dehydroanomuricine- N -oxide and anomuricine were also isolated. The structures of these compounds were determined by spectroscopic and spectrometric techniques. The cytotoxic capacity of crude methanolic extract and the alkaloidal fraction were evaluated, showing moderate cytotoxicity. The isolation and identification of these alkaloids are an important contribution to the chemotaxonomy of the genus Annona and the Annonaceae family.

中文翻译:

从 atemoya (Annona cherimola × Annona squamosa) 的叶子中分离出一种新的 N-氧化物苄基异喹啉生物碱

通过 LC-MS-IT 对 atemoya 地上部分进行了植物化学研究,并评估了细胞毒活性。这些结果导致鉴定了一种新的 N - 氧化物生物碱(脱氢抗鼠药碱 - N - 氧化物)和其他八种生物碱:scoulerine、reticuline、isocoorydine、norisocorydine、asimilobine、nornuciferine、anonaine 和 liriodenine。还分离了新的生物碱脱氢抗鼠碱-N-氧化物和抗鼠药。这些化合物的结构是通过光谱和光谱技术确定的。评估了粗甲醇提取物和生物碱部分的细胞毒性能力,显示出中等的细胞毒性。这些生物碱的分离和鉴定对番荔枝属和番荔枝科的化学分类学做出了重要贡献。
更新日期:2021-07-06
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