A simple and efficient method has been developed for construction of 3-(2-(1,3,4-thiadiazol-2-ylamino)acetyl)-2H-selenopyrano[2,3-b]quinolin-2-ones (3a–f). The 3-acetyl-2H-selenopyrano[2,3-b]quinolin-2-ones (1a–f) on bromination with glacial acetic acid offered 3-(2-bromoacetyl)-2H-selenopyrano[2,3-b]quinolin-2-ones (2a–f), these intermediates undergoes coupling with 1,3,4-thiadiazol-2-amine in the presence of potassium carbonate in dimethylformamide to get the title compounds. The present methodology provides an attractive approach to various substituted 3-acetyl-2H-selenopyrano[2,3-b]quinolin-2-ones ring with the 1,3,4-thiadiazol-2-amine heterocycle in one condensed molecule in moderate to good yields with favorable functional group tolerance, which has the advantages of operation simplicity, readily available starting materials, scale-up synthesis.

一种简单且有效的方法已被开发用于3-施工（2-（1,3,4-噻二唑-2-基氨基）乙酰基）-2- ħ -selenopyrano [2,3- b ]喹啉-2-酮（3A -f)。3-乙酰基-2 H-硒吡喃并[2,3 - b ]喹啉-2-酮（1a-f）用冰醋酸溴化得到3-（2-溴乙酰基）-2 H-硒吡喃并[2,3- b ]quinolin-2-ones (2a–f)，这些中间体在碳酸钾的存在下在二甲基甲酰胺中与 1,3,4-噻二唑-2-胺偶联，得到标题化合物。本方法为各种取代的 3-乙酰基-2 H提供了一种有吸引力的方法-硒吡喃并[2,3 - b ]喹啉-2-酮环与1,3,4-噻二唑-2-胺杂环在一个缩合分子中，产率中等至良好，具有良好的官能团耐受性，具有操作优势简单，易得的起始材料，放大合成。