Traumatic brain injury (TBI) can result in left ventricular dysfunction, which can lead to hypotension and secondary brain injuries. However, the association between left ventricular systolic dysfunction (LVSD) and in-hospital mortality in patients with moderate-to-severe isolated TBI is controversial. Therefore, we conducted a systematic review and meta-analysis to identify the prevalence of LVSD and evaluate whether LVSD following moderate-to-severe isolated TBI increases the in-hospital mortality. We searched PubMed, EMBASE, and the Cochrane Library database from January 1, 2010, through June 30, 2020. Meta-analysis was performed to determine the incidence of LVSD and related mortality in patients with moderate-to-severe isolated TBI. A systematic review identified 5 articles appropriate for meta-analysis. The total number of patients pooled was 256. LVSD was reported in 4 studies, of which the estimated incidence of patients with LVSD was 18.7% (95% confidence interval, 11.9–26.6). Five studies reported on in-hospital mortality, and the estimated in-hospital mortality was 14.1% (95% confidence interval, 5.3–25.6). Finally, 3 studies were eligible for analyzing the association of LVSD and in-hospital mortality. On meta-analysis, in-hospital mortality was significantly higher in patients with LVSD (risk ratio, 6.57; 95% confidence interval, 3.71–11.65; P < 0.001). In conclusion, LVSD after moderate-to-severe TBI is common and may be associated with worse in-hospital outcomes.

创伤性脑损伤 (TBI) 可导致左心室功能障碍，从而导致低血压和继发性脑损伤。然而，中重度孤立性 TBI 患者的左心室收缩功能障碍 (LVSD) 与院内死亡率之间的关系存在争议。因此，我们进行了系统回顾和荟萃分析，以确定 LVSD 的患病率，并评估中度至重度孤立性 TBI 后的 LVSD 是否会增加院内死亡率。我们检索了 2010 年 1 月 1 日至 2020 年 6 月 30 日期间的 PubMed、EMBASE 和 Cochrane 图书馆数据库。进行荟萃分析以确定中重度孤立性 TBI 患者的 LVSD 发生率和相关死亡率。系统评价确定了 5 篇适合荟萃分析的文章。合并的患者总数为 256 例。4 项研究报告了 LVSD，其中 LVSD 患者的估计发生率为 18.7%（95% 置信区间，11.9-26.6）。五项研究报告了院内死亡率，估计院内死亡率为 14.1%（95% 置信区间，5.3-25.6）。最后，3 项研究符合分析 LVSD 与院内死亡率之间关系的条件。荟萃分析显示，LVSD 患者的院内死亡率显着较高（风险比，6.57；95% 置信区间，3.71–11.65；P < 0.001）。总之，中度至重度 TBI 后的 LVSD 很常见，并且可能与较差的院内结局相关。