Abstract

Nanosponges, porous nanocarriers were explored for encapsulation of carboplatin by employing a quality by design approach. Nanosponges were prepared by double emulsion solvent evaporation using the central composite design. Ethylcellulose, 450 mg, polyvinyl alcohol, 2.3% (w/v) and phase evaporation rate, 760 rpm yielded the optimized spherical particles of size 272.92 ± 12.31 nm, PDI 0.390, with zeta charge of −22.3 mV. The entrapment efficiency of carboplatin-loaded nanosponges was 56.27 ± 2.52%. A sustained carboplatin release of 79.03% and 95.94% within 12 h at pH 4.5 and 6.8, respectively suggested that nanosponges could be promising carriers for sustained release of hydrophilic therapeutic candidates.

摘要

通过采用质量源于设计的方法，探索了纳米海绵、多孔纳米载体以包封卡铂。使用中心复合设计通过双乳液溶剂蒸发制备纳米海绵。乙基纤维素，450 mg，聚乙烯醇，2.3% (w/v) 和相蒸发速率，760 rpm 产生尺寸为 272.92 ± 12.31 nm，PDI 0.390 的优化球形颗粒，zeta 电荷为 -22.3 mV。载有卡铂的纳米海绵的包封率为 56.27 ± 2.52%。在 pH 值 4.5 和 6.8 下，12 小时内卡铂的持续释放率分别为 79.03% 和 95.94%，这表明纳米海绵可能是用于持续释放亲水性治疗候选物的有希望的载体。