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Prenatal urinary concentrations of phenols and risk of preterm birth: exploring windows of vulnerability
Fertility and Sterility ( IF 6.7 ) Pub Date : 2021-07-06 , DOI: 10.1016/j.fertnstert.2021.03.053
Yu Zhang 1 , Vicente Mustieles 2 , Paige L Williams 3 , Jennifer Yland 4 , Irene Souter 5 , Joseph M Braun 6 , Antonia M Calafat 7 , Russ Hauser 8 , Carmen Messerlian 9
Affiliation  

Objective

To explore windows of vulnerability to prenatal urinary phenol concentrations and preterm birth.

Design

Prospective cohort.

Setting

A large fertility center in Boston, Massachusetts.

Patient(s)

A total of 386 mothers who sought fertility treatment and gave birth to a singleton between 2005 and 2018.

Intervention(s)

None.

Main outcome measure(s)

Singleton live birth with gestational age <37 completed weeks.

Result(s)

Compared with women with non-preterm births, urinary bisphenol A (BPA) concentrations were higher across gestation among women with preterm births, particularly during mid-to-late pregnancy and among those with female infants. Second trimester BPA concentrations were associated with preterm birth (Risk Ratio [RR] 1.24; 95%CI: 0.92, 1.69), which was primarily driven by female (RR 1.40; 95%CI: 1.04, 1.89) and not male (RR 0.85; 95%CI 0.50, 1.46) infants. First trimester paraben concentrations were also associated with preterm birth (RR 1.17; 95%CI: 0.94, 1.46) and similarly the association was only observed for female (RR 1.46; 95% CI: 1.10, 1.94) and not male infants (RR 0.94; 95%CIC: 0.72, 1.23). First trimester urinary bisphenol S concentrations showed a suggested risk of preterm birth (RR 1.25; 95%CI: 0.82, 1.89), although the small case numbers precluded sex-specific examination.

Conclusion(s)

We found preliminary evidence of associations between mid-to-late pregnancy BPA and early pregnancy paraben concentrations with preterm birth among those with female infants only. Preterm birth risk may be compound, sex, and window specific. Given the limited sample size of this cohort, results should be confirmed in larger studies, including fertile populations.



中文翻译:

苯酚的产前尿浓度和早产风险:探索脆弱性窗口

客观的

探索易受产前尿酚浓度和早产影响的窗口。

设计

前瞻性队列。

环境

马萨诸塞州波士顿的一个大型生育中心。

患者)

2005年至2018年间,共有386名母亲寻求生育治疗并生下单胎。

干预措施

没有任何。

主要观察指标)

单胎活产,胎龄<37 周。

结果)

与非早产的女性相比,早产女性的妊娠期尿双酚 A (BPA) 浓度较高,尤其是在妊娠中后期和有女婴的女性中。孕中期 BPA 浓度与早产相关(风险比 [RR] 1.24;95%CI:0.92, 1.69),这主要由女性(RR 1.40;95%CI:1.04, 1.89)而非男性(RR 0.85)驱动; 95%CI 0.50, 1.46) 婴儿。孕早期对羟基苯甲酸酯浓度也与早产相关(RR 1.17;95%CI:0.94, 1.46),类似地,这种关联仅在女性(RR 1.46;95% CI:1.10, 1.94)而非男婴(RR 0.94)中观察到; 95%CIC:0.72, 1.23)。孕早期尿双酚 S 浓度显示有早产风险(RR 1.25;95%CI:0.82, 1.89),

结论

我们发现了中晚期妊娠 BPA 和妊娠早期对羟基苯甲酸酯浓度与仅女婴早产之间关联的初步证据。早产风险可能是复合的、性别的和窗口特定的。鉴于该队列的样本量有限,结果应在更大的研究中得到证实,包括肥沃的人群。

更新日期:2021-08-27
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