Exposure to alternative phthalates and related health effects in pregnant women are rarely reported. Nineteen phthalate metabolites and a DNA oxidative damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) were determined in urine samples of pregnant women recruited in South China. The detection frequencies and concentration of selected alternative phthalates, i.e., diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP) and di-(2-propylheptyl) phthalate (DPHP) were lower than those of conventional phthalates. However, mono-(6-hydroxy-2-propylheptyl) phthalate, a metabolite of DPHP, was detected in 70% of urine samples (median: 0.13 ng/mL). The estimated daily intakes of conventional plasticizers, including dimethyl phthalate, di-n-butyl phthalate, diisobutyl phthalate and di-(2-ethylhexyl) phthalate (median range: 1.0–3.0 μg/kg_bw/day) were significantly higher than those of DiNP (0.08 μg/kg_bw/day) and DPHP (0.03 μg/kg_bw/day) (p < 0.05). Approximately 24% of pregnant women were at high risk when cumulative risk from exposure to several phthalates was considered. The concentrations of phthalate metabolites and urinary 8-OHdG were significantly correlated with each other (r = 0.206–0.772, p < 0.01), which were further conformed by multiple linear regression analysis (β = 0.168–0.639, p < 0.01). In addition, conventional phthalates were more strongly correlated with 8-OHdG than alternative phthalates (i.e., DiNP, DPHP), partly suggesting the relatively smaller health effects of alternatives due to their low exposure doses and toxicities. These findings suggested that alternative phthalates have entered the human body from consumer products in the study area, and exposure-related risk of DNA oxidative stress was comparatively lower.

孕妇接触替代邻苯二甲酸酯和相关健康影响的报道很少。在华南地区招募的孕妇尿样中测定了 19 种邻苯二甲酸酯代谢物和 DNA 氧化损伤生物标志物 8-羟基-2'-脱氧鸟苷 (8-OHdG)。所选择的邻苯二甲酸二异壬酯（DiNP）、邻苯二甲酸二异癸酯（DiDP）和邻苯二甲酸二（2-丙基庚基）酯（DPHP）的检测频率和浓度低于常规邻苯二甲酸酯。然而，在 70% 的尿液样本中检测到邻苯二甲酸单（6-羟基-2-丙基庚基）酯，一种 DPHP 的代谢物（中值：0.13 ng/mL）。常规增塑剂的估计每日摄入量，包括邻苯二甲酸二甲酯、邻苯二甲酸二正丁酯、邻苯二甲酸二异丁酯和邻苯二甲酸二（2-乙基己基）酯（中值范围：1.0-3.p  < 0.05)。当考虑到接触几种邻苯二甲酸酯的累积风险时，大约 24% 的孕妇处于高风险中。邻苯二甲酸酯代谢物和尿中 8-OHdG 的浓度显着相关 ( r  = 0.206–0.772, p  < 0.01)，多元线性回归分析进一步符合 ( β =  0.168–0.639, p < 0.01)。此外，与替代邻苯二甲酸酯（即 DiNP、DPHP）相比，传统邻苯二甲酸酯与 8-OHdG 的相关性更强，部分表明替代品由于其低暴露剂量和毒性而对健康的影响相对较小。这些发现表明，替代邻苯二甲酸酯已经从研究区域的消费品进入人体，与暴露相关的 DNA 氧化应激风险相对较低。