The prediction of crystal structures assembled in three dimensions has been considered for a long time, simultaneously as a chemical wasteland and a certain growth point of the chemistry of the future. Less than 30 years after Roald Hoffmann’s statement, we can categorically affirm that the elevation of reticular chemistry and the introduction of metal–organic frameworks (MOFs) significantly tackled this tridimensional assembly issue. MOFs result from the assembly of organic polytopic organic ligands bridging metal nodes, clusters, chains, or layers together into mostly three-periodic open frameworks. They can exhibit extremely high porosity and offer great potential as revolutionary catalysts, drug carrier systems, sensors, smart materials, and, of course, separation agents. Overall, the progressive development of reticular chemistry has been a game changer in materials chemistry during the last 25 years.

中文翻译：

---

高度连接的建筑单元在网状化学中的重要性：金属-有机框架的深思熟虑的设计

三维组装晶体结构的预测长期以来一直被考虑，同时作为化学荒地和未来化学的一定增长点。在罗尔德·霍夫曼 (Roald Hoffmann) 发表声明后不到 30 年，我们可以断然肯定，网状化学的提升和金属有机框架 (MOF) 的引入显着解决了这个三维组装问题。MOF 是由有机多面体有机配体组装而成，将金属节点、簇、链或层连接在一起，形成主要的三周期开放框架。它们具有极高的孔隙率，并具有作为革命性催化剂、药物载体系统、传感器、智能材料，当然还有分离剂的巨大潜力。总体，